BCO2 (beta-carotene oxygenase 2)

2017-10-01  

Identity

HGNC
BCO2
LOCATION
11q23.1
LOCUSID
83875
ALIAS
B-DIOX-II,BCDO2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83875
MIM: 611740
HGNC: 18503
Ensembl: ENSG00000197580

Variants:

dbSNP: 83875
ClinVar: 83875
TCGA: ENSG00000197580
COSMIC: BCO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197580ENST00000357685Q9BYV7
ENSG00000197580ENST00000361053Q9BYV7
ENSG00000197580ENST00000438022Q9BYV7
ENSG00000197580ENST00000525175H0YCL7
ENSG00000197580ENST00000526088Q9BYV7
ENSG00000197580ENST00000527939E9PPP9
ENSG00000197580ENST00000530677H0YCN8
ENSG00000197580ENST00000531003E9PS89
ENSG00000197580ENST00000531169Q9BYV7
ENSG00000197580ENST00000532593Q9BYV7
ENSG00000197580ENST00000532612V9GYA9
ENSG00000197580ENST00000534550E9PPP9

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
Retinoid metabolism and transportREACTOMER-HSA-975634
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of fat-soluble vitaminsREACTOMER-HSA-6806667

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
retina
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
320352292020Enzymology of vertebrate carotenoid oxygenases.17
320617502020Evolutionary aspects and enzymology of metazoan carotenoid cleavage oxygenases.12
328737062020The human mitochondrial enzyme BCO2 exhibits catalytic activity toward carotenoids and apocarotenoids.19
320352292020Enzymology of vertebrate carotenoid oxygenases.17
320617502020Evolutionary aspects and enzymology of metazoan carotenoid cleavage oxygenases.12
328737062020The human mitochondrial enzyme BCO2 exhibits catalytic activity toward carotenoids and apocarotenoids.19
312505802019Associations for BCO2, PCSK9, and TR1B1 Polymorphism and Lifestyle Factors with Ischemic Stroke: A Nested Case-Control Study.5
312505802019Associations for BCO2, PCSK9, and TR1B1 Polymorphism and Lifestyle Factors with Ischemic Stroke: A Nested Case-Control Study.5
273902652016Molecular aspects of β, β-carotene-9', 10'-oxygenase 2 in carotenoid metabolism and diseases.18
274068262016Mitochondrial β-Carotene 9',10' Oxygenase Modulates Prostate Cancer Growth via NF-κB Inhibition: A Lycopene-Independent Function.20
273902652016Molecular aspects of β, β-carotene-9', 10'-oxygenase 2 in carotenoid metabolism and diseases.18
274068262016Mitochondrial β-Carotene 9',10' Oxygenase Modulates Prostate Cancer Growth via NF-κB Inhibition: A Lycopene-Independent Function.20
263070712015Characterization of the Role of β-Carotene 9,10-Dioxygenase in Macular Pigment Metabolism.39
263070712015Characterization of the Role of β-Carotene 9,10-Dioxygenase in Macular Pigment Metabolism.39
249821312014Inactivity of human β,β-carotene-9',10'-dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigment.60

Citation

Dessen P

BCO2 (beta-carotene oxygenase 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57069/bco2-(beta-carotene-oxygenase-2)