BCO2 (beta-carotene oxygenase 2)

2017-10-01  

Identity

HGNC
LOCATION
11q23.1
LOCUSID
ALIAS
B-DIOX-II,BCDO2
FUSION GENES

Other Information

Locus ID:

NCBI: 83875
MIM: 611740
HGNC: 18503
Ensembl: ENSG00000197580

Variants:

dbSNP: 83875
ClinVar: 83875
TCGA: ENSG00000197580
COSMIC: BCO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197580ENST00000357685Q9BYV7
ENSG00000197580ENST00000361053Q9BYV7
ENSG00000197580ENST00000438022Q9BYV7
ENSG00000197580ENST00000525175H0YCL7
ENSG00000197580ENST00000526088Q9BYV7
ENSG00000197580ENST00000527939E9PPP9
ENSG00000197580ENST00000530677H0YCN8
ENSG00000197580ENST00000531003E9PS89
ENSG00000197580ENST00000531169Q9BYV7
ENSG00000197580ENST00000532593Q9BYV7
ENSG00000197580ENST00000532612V9GYA9
ENSG00000197580ENST00000534550E9PPP9

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
Retinoid metabolism and transportREACTOMER-HSA-975634
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of fat-soluble vitaminsREACTOMER-HSA-6806667

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
211069342011A mitochondrial enzyme degrades carotenoids and protects against oxidative stress.89
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
241062812013Two carotenoid oxygenases contribute to mammalian provitamin A metabolism.44
249821312014Inactivity of human β,β-carotene-9',10'-dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigment.36
263070712015Characterization of the Role of β-Carotene 9,10-Dioxygenase in Macular Pigment Metabolism.24
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
274068262016Mitochondrial β-Carotene 9',10' Oxygenase Modulates Prostate Cancer Growth via NF-κB Inhibition: A Lycopene-Independent Function.9
273902652016Molecular aspects of β, β-carotene-9', 10'-oxygenase 2 in carotenoid metabolism and diseases.8
213021312011Production of β-apo-10'-carotenal from β-carotene by human β-carotene-9',10'-oxygenase expressed in E. coli.4
312505802019Associations for BCO2, PCSK9, and TR1B1 Polymorphism and Lifestyle Factors with Ischemic Stroke: A Nested Case-Control Study.2

Citation

Dessen P

BCO2 (beta-carotene oxygenase 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57069/bco2-(beta-carotene-oxygenase-2)