Identity
HGNC
LOCATION
21q21.3
LOCUSID
ALIAS
C21orf127,HEMK2,KMT9,MTQ2,N6AMT,PRED28,PrmC,m.HsaHemK2P
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 29104
MIM: 614553
HGNC: 16021
Ensembl: ENSG00000156239
Variants:
dbSNP: 29104
ClinVar: 29104
TCGA: ENSG00000156239
COSMIC: N6AMT1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000156239 | ENST00000303775 | Q9Y5N5 |
| ENSG00000156239 | ENST00000351429 | Q9Y5N5 |
| ENSG00000156239 | ENST00000460212 | Q9Y5N5 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166129560 | major adverse cardiac events (mace) | Disease | ClinicalAnnotation | associated | PK | PD | |
| PA449053 | clopidogrel | Chemical | ClinicalAnnotation | associated | PK | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38284488 | 2024 | Distinct specificities of the HEMK2 protein methyltransferase in methylation of glutamine and lysine residues. | 0 |
| 38284488 | 2024 | Distinct specificities of the HEMK2 protein methyltransferase in methylation of glutamine and lysine residues. | 0 |
| 36681142 | 2023 | Arsenic metabolism, N6AMT1 and AS3MT single nucleotide polymorphisms, and their interaction on gestational diabetes mellitus in Chinese pregnant women. | 3 |
| 36681142 | 2023 | Arsenic metabolism, N6AMT1 and AS3MT single nucleotide polymorphisms, and their interaction on gestational diabetes mellitus in Chinese pregnant women. | 3 |
| 34737213 | 2022 | KMT9 Controls Stemness and Growth of Colorectal Cancer. | 15 |
| 35256595 | 2022 | Reducing N6AMT1-mediated 6mA DNA modification promotes breast tumor progression via transcriptional repressing cell cycle inhibitors. | 10 |
| 34737213 | 2022 | KMT9 Controls Stemness and Growth of Colorectal Cancer. | 15 |
| 35256595 | 2022 | Reducing N6AMT1-mediated 6mA DNA modification promotes breast tumor progression via transcriptional repressing cell cycle inhibitors. | 10 |
| 32969463 | 2020 | Structural insight into HEMK2-TRMT112-mediated glutamine methylation. | 6 |
| 32969463 | 2020 | Structural insight into HEMK2-TRMT112-mediated glutamine methylation. | 6 |
| 31061526 | 2019 | KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells. | 39 |
| 31466382 | 2019 | The Common Partner of Several Methyltransferases TRMT112 Regulates the Expression of N6AMT1 Isoforms in Mammalian Cells. | 9 |
| 31061526 | 2019 | KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells. | 39 |
| 31466382 | 2019 | The Common Partner of Several Methyltransferases TRMT112 Regulates the Expression of N6AMT1 Isoforms in Mammalian Cells. | 9 |
| 30017583 | 2018 | N(6)-Methyladenine DNA Modification in the Human Genome. | 221 |
Citation
Dessen P
N6AMT1 (N-6 adenine-specific DNA methyltransferase 1)
Atlas Genet Cytogenet Oncol Haematol. 2017-10-01
Online version: http://atlasgeneticsoncology.org/gene/57077/n6amt1-(n-6-adenine-specific-dna-methyltransferase-1)
