Identity
HGNC
LOCATION
21q22.3
LOCUSID
ALIAS
GAMOS6,MIGSB,TRM82,TRMT82,Wuho,hWH
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10785
MIM: 605924
HGNC: 12756
Ensembl: ENSG00000160193
Variants:
dbSNP: 10785
ClinVar: 10785
TCGA: ENSG00000160193
COSMIC: WDR4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000160193 | ENST00000330317 | P57081 |
| ENSG00000160193 | ENST00000398208 | P57081 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Gene Expression | REACTOME | R-HSA-74160 |
| tRNA processing | REACTOME | R-HSA-72306 |
| tRNA modification in the nucleus and cytosol | REACTOME | R-HSA-6782315 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38493882 | 2024 | WDR4 promotes HCC pathogenesis through N(7)-methylguanosine by regulating and interacting with METTL1. | 1 |
| 38493882 | 2024 | WDR4 promotes HCC pathogenesis through N(7)-methylguanosine by regulating and interacting with METTL1. | 1 |
| 36599982 | 2023 | Structures and mechanisms of tRNA methylation by METTL1-WDR4. | 23 |
| 36599985 | 2023 | Structural basis of regulated m(7)G tRNA modification by METTL1-WDR4. | 20 |
| 36681682 | 2023 | Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation. | 1 |
| 36733406 | 2023 | Association of RNA m(7)G Modification Gene Polymorphisms with Pediatric Glioma Risk. | 1 |
| 37185458 | 2023 | METTL1/WDR4-mediated tRNA m(7)G modification and mRNA translation control promote oncogenesis and doxorubicin resistance. | 4 |
| 37279851 | 2023 | WDR4/TRIM28 is a novel molecular target linked to lenvatinib resistance that helps retain the stem characteristics in hepatocellular carcinomas. | 2 |
| 37821451 | 2023 | PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target. | 2 |
| 36599982 | 2023 | Structures and mechanisms of tRNA methylation by METTL1-WDR4. | 23 |
| 36599985 | 2023 | Structural basis of regulated m(7)G tRNA modification by METTL1-WDR4. | 20 |
| 36681682 | 2023 | Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation. | 1 |
| 36733406 | 2023 | Association of RNA m(7)G Modification Gene Polymorphisms with Pediatric Glioma Risk. | 1 |
| 37185458 | 2023 | METTL1/WDR4-mediated tRNA m(7)G modification and mRNA translation control promote oncogenesis and doxorubicin resistance. | 4 |
| 37279851 | 2023 | WDR4/TRIM28 is a novel molecular target linked to lenvatinib resistance that helps retain the stem characteristics in hepatocellular carcinomas. | 2 |
Citation
Dessen P
WDR4 (WD repeat domain 4)
Atlas Genet Cytogenet Oncol Haematol. 2017-10-01
Online version: http://atlasgeneticsoncology.org/gene/57078/wdr4-(wd-repeat-domain-4)
