Identity
HGNC
LOCATION
6q24.1
LOCUSID
ALIAS
C6ORF34B,C6orf34,PP23,SOUL
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23593
MIM: 605825
HGNC: 15716
Ensembl: ENSG00000051620
Variants:
dbSNP: 23593
ClinVar: 23593
TCGA: ENSG00000051620
COSMIC: HEBP2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000051620 | ENST00000367697 | Q5THN1 |
| ENSG00000051620 | ENST00000448741 | C9IZA0 |
| ENSG00000051620 | ENST00000453452 | H7C0N7 |
| ENSG00000051620 | ENST00000607197 | Q9Y5Z4 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Innate Immune System | REACTOME | R-HSA-168249 |
| Neutrophil degranulation | REACTOME | R-HSA-6798695 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 28004381 | 2017 | Deregulated ALG-2/HEBP2 axis alters microtubule dynamics and mitotic spindle behavior to stimulate cancer development. | 7 |
| 28004381 | 2017 | Deregulated ALG-2/HEBP2 axis alters microtubule dynamics and mitotic spindle behavior to stimulate cancer development. | 7 |
| 21639858 | 2011 | Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL. | 14 |
| 21639858 | 2011 | Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL. | 14 |
| 19901022 | 2010 | Facilitation of mitochondrial outer and inner membrane permeabilization and cell death in oxidative stress by a novel Bcl-2 homology 3 domain protein. | 13 |
| 19901022 | 2010 | Facilitation of mitochondrial outer and inner membrane permeabilization and cell death in oxidative stress by a novel Bcl-2 homology 3 domain protein. | 13 |
| 19574650 | 2009 | Preliminary structural characterization of human SOUL, a haem-binding protein. | 1 |
| 19574650 | 2009 | Preliminary structural characterization of human SOUL, a haem-binding protein. | 1 |
| 17098234 | 2006 | Induction of necrotic cell death and mitochondrial permeabilization by heme binding protein 2/SOUL. | 15 |
| 17098234 | 2006 | Induction of necrotic cell death and mitochondrial permeabilization by heme binding protein 2/SOUL. | 15 |
Citation
Dessen P
HEBP2 (heme binding protein 2)
Atlas Genet Cytogenet Oncol Haematol. 2017-10-01
Online version: http://atlasgeneticsoncology.org/gene/57082/hebp2-(heme-binding-protein-2)
