CGAS (cyclic GMP-AMP synthase)

2017-10-01  

Identity

HGNC
CGAS
LOCATION
6q13
LOCUSID
115004
ALIAS
C6orf150,MB21D1,h-cGAS

Other Information

Locus ID:

NCBI: 115004
MIM: 613973
HGNC: 21367
Ensembl: ENSG00000164430

Variants:

dbSNP: 115004
ClinVar: 115004
TCGA: ENSG00000164430
COSMIC: CGAS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164430ENST00000370315Q8N884
ENSG00000164430ENST00000370318Q8N884

Pathways

PathwaySourceExternal ID
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
STING mediated induction of host immune responsesREACTOMER-HSA-1834941

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379317702024cGAS-STING at the crossroads in cancer therapy.1
379489792024Role of cGAS-STING in colorectal cancer: A new window for treatment strategies.0
379569182024Cardiovascular diseases crossroads: cGAS-STING signaling and disease progression.2
380548922024The UAF1-USP1 Deubiquitinase Complex Stabilizes cGAS and Facilitates Antiviral Responses.0
380563692024Potential cGAS-STING pathway functions in DNA damage responses, DNA replication and DNA repair.0
381484532024cGAS Mediates the Inflammatory Responses of Human Microglial Cells to Genotoxic DNA Damage.0
382003092024MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis.9
382160062024IUPHAR ECR review: The cGAS-STING pathway: Novel functions beyond innate immune and emerging therapeutic opportunities.0
382407032024Molecular map of cGAS-STING pathway-related genes in bladder cancer: the perspective toward immune microenvironment and prognosis.0
382778172024FBXO38 deficiency promotes lysosome-dependent STING degradation and inhibits cGAS-STING pathway activation.1
383310882024Arginine methylation-dependent cGAS stability promotes non-small cell lung cancer cell proliferation.0
383891032024Hypoxic glioblastoma-cell-derived extracellular vesicles impair cGAS-STING activity in macrophages.2
384188822024The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation.2
384243122024Severe COVID-19 and long COVID are associated with high expression of STING, cGAS and IFN-α.1
384596582024The cytosolic DNA-sensing cGAS-STING pathway in neurodegenerative diseases.1

Citation

Dessen P

CGAS (cyclic GMP-AMP synthase)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57109