CGAS (cyclic GMP-AMP synthase)

2017-10-01  

Identity

HGNC
LOCATION
6q13
LOCUSID
ALIAS
C6orf150,MB21D1,h-cGAS

Other Information

Locus ID:

NCBI: 115004
MIM: 613973
HGNC: 21367
Ensembl: ENSG00000164430

Variants:

dbSNP: 115004
ClinVar: 115004
TCGA: ENSG00000164430
COSMIC: CGAS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164430ENST00000370315Q8N884
ENSG00000164430ENST00000370318Q8N884

Pathways

PathwaySourceExternal ID
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
STING mediated induction of host immune responsesREACTOMER-HSA-1834941

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
232584132013Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.951
239299452013Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses.330
237070652013The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING.211
287384082017cGAS surveillance of micronuclei links genome instability to innate immunity.172
237221592013Structural mechanism of cytosolic DNA sensing by cGAS.155
242691712013The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells.143
285333622017cGAS is essential for cellular senescence.131
260481382015Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1.126
260481372015Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis.118
245288682014Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses.105

Citation

Dessen P

CGAS (cyclic GMP-AMP synthase)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57109/cgas-(cyclic-gmp-amp-synthase)