Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 115004
MIM: 613973
HGNC: 21367
Ensembl: ENSG00000164430
Variants:
dbSNP: 115004
ClinVar: 115004
TCGA: ENSG00000164430
COSMIC: CGAS
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000164430 | ENST00000370315 | Q8N884 |
| ENSG00000164430 | ENST00000370318 | Q8N884 |
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37931770 | 2024 | cGAS-STING at the crossroads in cancer therapy. | 1 |
| 37948979 | 2024 | Role of cGAS-STING in colorectal cancer: A new window for treatment strategies. | 0 |
| 37956918 | 2024 | Cardiovascular diseases crossroads: cGAS-STING signaling and disease progression. | 2 |
| 38054892 | 2024 | The UAF1-USP1 Deubiquitinase Complex Stabilizes cGAS and Facilitates Antiviral Responses. | 0 |
| 38056369 | 2024 | Potential cGAS-STING pathway functions in DNA damage responses, DNA replication and DNA repair. | 0 |
| 38148453 | 2024 | cGAS Mediates the Inflammatory Responses of Human Microglial Cells to Genotoxic DNA Damage. | 0 |
| 38200309 | 2024 | MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis. | 9 |
| 38216006 | 2024 | IUPHAR ECR review: The cGAS-STING pathway: Novel functions beyond innate immune and emerging therapeutic opportunities. | 0 |
| 38240703 | 2024 | Molecular map of cGAS-STING pathway-related genes in bladder cancer: the perspective toward immune microenvironment and prognosis. | 0 |
| 38277817 | 2024 | FBXO38 deficiency promotes lysosome-dependent STING degradation and inhibits cGAS-STING pathway activation. | 1 |
| 38331088 | 2024 | Arginine methylation-dependent cGAS stability promotes non-small cell lung cancer cell proliferation. | 0 |
| 38389103 | 2024 | Hypoxic glioblastoma-cell-derived extracellular vesicles impair cGAS-STING activity in macrophages. | 2 |
| 38418882 | 2024 | The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation. | 2 |
| 38424312 | 2024 | Severe COVID-19 and long COVID are associated with high expression of STING, cGAS and IFN-α. | 1 |
| 38459658 | 2024 | The cytosolic DNA-sensing cGAS-STING pathway in neurodegenerative diseases. | 1 |
Citation
Dessen P
CGAS (cyclic GMP-AMP synthase)
Atlas Genet Cytogenet Oncol Haematol. 2017-10-01
Online version: http://atlasgeneticsoncology.org/gene/57109/cgas-(cyclic-gmp-amp-synthase)
