Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 64077
MIM: 617231
HGNC: 30042
Ensembl: ENSG00000107902
Variants:
dbSNP: 64077
ClinVar: 64077
TCGA: ENSG00000107902
COSMIC: LHPP
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000107902 | ENST00000368839 | Q9H008 |
| ENSG00000107902 | ENST00000368842 | Q9H008 |
| ENSG00000107902 | ENST00000392757 | Q5T1Z0 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36355716 | 2023 | Identification of Tumor Suppressor Gene LHPP-Based 5-microRNA Signature That Predicts the Early- and Midstage Esophageal Squamous Cell Carcinoma: A Two-Stage Case-Control Study in the Chinese Han Population. | 0 |
| 36546683 | 2023 | LHPP promotes the intracellular reactive oxygen species accumulation and sensitivity of gastric cancer to cisplatin via JNK and p38 MAPK pathways. | 2 |
| 37321804 | 2023 | LHPP Inhibits the Viability, Migration, and Proliferation of PDAC Cells and Significantly Affects the Expression of SDC1 and S100p. | 3 |
| 36355716 | 2023 | Identification of Tumor Suppressor Gene LHPP-Based 5-microRNA Signature That Predicts the Early- and Midstage Esophageal Squamous Cell Carcinoma: A Two-Stage Case-Control Study in the Chinese Han Population. | 0 |
| 36546683 | 2023 | LHPP promotes the intracellular reactive oxygen species accumulation and sensitivity of gastric cancer to cisplatin via JNK and p38 MAPK pathways. | 2 |
| 37321804 | 2023 | LHPP Inhibits the Viability, Migration, and Proliferation of PDAC Cells and Significantly Affects the Expression of SDC1 and S100p. | 3 |
| 35002505 | 2022 | As a Novel Tumor Suppressor, LHPP Promotes Apoptosis by Inhibiting the PI3K/AKT Signaling Pathway in Oral Squamous Cell Carcinoma. | 14 |
| 35796893 | 2022 | Tumor suppressor LHPP suppresses cell proliferation and epithelial-mesenchymal transition in hepatocellular carcinoma cell lines. | 4 |
| 35002505 | 2022 | As a Novel Tumor Suppressor, LHPP Promotes Apoptosis by Inhibiting the PI3K/AKT Signaling Pathway in Oral Squamous Cell Carcinoma. | 14 |
| 35796893 | 2022 | Tumor suppressor LHPP suppresses cell proliferation and epithelial-mesenchymal transition in hepatocellular carcinoma cell lines. | 4 |
| 33368780 | 2021 | Purpurin binding interacts with LHPP protein that inhibits PI3K/AKT phosphorylation and induces apoptosis in colon cancer cells HCT-116. | 8 |
| 33394310 | 2021 | LHPP exerts a tumor-inhibiting role in glioblastoma via the downregulation of Akt and Wnt/β-catenin signaling. | 7 |
| 33401010 | 2021 | LHPP suppresses tumorigenesis of intrahepatic cholangiocarcinoma by inhibiting the TGFβ/smad signaling pathway. | 7 |
| 34099278 | 2021 | Prognostic Correlation of Glycolysis-Related Gene Signature in Patients with Laryngeal Cancer. | 5 |
| 34699621 | 2021 | Three LHPP gene-targeting co-expressed microRNAs (microRNA-765, microRNA-21, and microRNA-144) promote proliferation, epithelial-mesenchymal transition, invasion, and are independent prognostic biomarkers in renal cell carcinomas patients. | 4 |
Citation
Dessen P
LHPP (phospholysine phosphohistidine inorganic pyrophosphate phosphatase)
Atlas Genet Cytogenet Oncol Haematol. 2017-10-01
Online version: http://atlasgeneticsoncology.org/gene/57116/lhpp-(phospholysine-phosphohistidine-inorganic-pyrophosphate-phosphatase)
