GPR31 (G protein-coupled receptor 31)

2017-10-01  

Identity

HGNC
LOCATION
6q27
LOCUSID
ALIAS
12-HETER,HETER,HETER1

Other Information

Locus ID:

NCBI: 2853
MIM: 602043
HGNC: 4486
Ensembl: ENSG00000120436

Variants:

dbSNP: 2853
ClinVar: 2853
TCGA: ENSG00000120436
COSMIC: GPR31

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120436ENST00000366834O00270

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Free fatty acid receptorsREACTOMER-HSA-444209

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
339724362021Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation.11
350115892021Expression of Proton-Sensitive GPR31, GPR151, TASK1 and TASK3 in Common Skin Tumors.3
339724362021Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation.11
350115892021Expression of Proton-Sensitive GPR31, GPR151, TASK1 and TASK3 in Common Skin Tumors.3
321656632020Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners.13
321656632020Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners.13
292274752018An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury.81
304163152018Overexpression of G protein-coupled receptor 31 as a poor prognosticator in human colorectal cancer.7
292274752018An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury.81
304163152018Overexpression of G protein-coupled receptor 31 as a poor prognosticator in human colorectal cancer.7
286197142017The G protein-coupled receptor GPR31 promotes membrane association of KRAS.15
286197142017The G protein-coupled receptor GPR31 promotes membrane association of KRAS.15
26965684201612-HETER1/GPR31, a high-affinity 12(S)-hydroxyeicosatetraenoic acid receptor, is significantly up-regulated in prostate cancer and plays a critical role in prostate cancer progression.18
26965684201612-HETER1/GPR31, a high-affinity 12(S)-hydroxyeicosatetraenoic acid receptor, is significantly up-regulated in prostate cancer and plays a critical role in prostate cancer progression.18
217123922011Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid.99

Citation

Dessen P

GPR31 (G protein-coupled receptor 31)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57120/gpr31-(g-protein-coupled-receptor-31)