Identity
HGNC
LOCATION
2q24.3
LOCUSID
ALIAS
AD024,SPBC25,hSpc25
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 57405
MIM: 609395
HGNC: 24031
Ensembl: ENSG00000152253
Variants:
dbSNP: 57405
ClinVar: 57405
TCGA: ENSG00000152253
COSMIC: SPC25
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000152253 | ENST00000282074 | Q9HBM1 |
| ENSG00000152253 | ENST00000451987 | C9JW94 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38217547 | 2024 | SPC25 as a novel therapeutic and prognostic biomarker and its association with glycolysis, ferroptosis and ceRNA in lung adenocarcinoma. | 0 |
| 38420826 | 2024 | SPC25 Functions as a Prognostic-Related Biomarker, and Its High Expression Correlates with Tumor Immune Infiltration and UCEC Progression. | 0 |
| 38217547 | 2024 | SPC25 as a novel therapeutic and prognostic biomarker and its association with glycolysis, ferroptosis and ceRNA in lung adenocarcinoma. | 0 |
| 38420826 | 2024 | SPC25 Functions as a Prognostic-Related Biomarker, and Its High Expression Correlates with Tumor Immune Infiltration and UCEC Progression. | 0 |
| 35293598 | 2022 | SPC25 promotes hepatocellular carcinoma metastasis via activating the FAK/PI3K/AKT signaling pathway through ITGB4. | 4 |
| 35967419 | 2022 | Spindle pole body component 25 and platelet-derived growth factor mediate crosstalk between tumor-associated macrophages and prostate cancer cells. | 4 |
| 36147467 | 2022 | SPC25 promotes proliferation and stemness of hepatocellular carcinoma cells via the DNA-PK/AKT/Notch1 signaling pathway. | 5 |
| 35293598 | 2022 | SPC25 promotes hepatocellular carcinoma metastasis via activating the FAK/PI3K/AKT signaling pathway through ITGB4. | 4 |
| 35967419 | 2022 | Spindle pole body component 25 and platelet-derived growth factor mediate crosstalk between tumor-associated macrophages and prostate cancer cells. | 4 |
| 36147467 | 2022 | SPC25 promotes proliferation and stemness of hepatocellular carcinoma cells via the DNA-PK/AKT/Notch1 signaling pathway. | 5 |
| 32351050 | 2020 | SPC25 may promote proliferation and metastasis of hepatocellular carcinoma via p53. | 9 |
| 33408271 | 2020 | SPC25 overexpression promotes tumor proliferation and is prognostic of poor survival in hepatocellular carcinoma. | 7 |
| 32351050 | 2020 | SPC25 may promote proliferation and metastasis of hepatocellular carcinoma via p53. | 9 |
| 33408271 | 2020 | SPC25 overexpression promotes tumor proliferation and is prognostic of poor survival in hepatocellular carcinoma. | 7 |
| 31400751 | 2019 | Up-regulation of SPC25 promotes breast cancer. | 17 |
Citation
Dessen P
SPC25 (SPC25 component of NDC80 kinetochore complex)
Atlas Genet Cytogenet Oncol Haematol. 2017-10-01
Online version: http://atlasgeneticsoncology.org/gene/57130/spc25-(spc25-component-of-ndc80-kinetochore-complex)
