Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 404203
MIM: 615868
HGNC: 29486
Ensembl: ENSG00000178172
Variants:
dbSNP: 404203
ClinVar: 404203
TCGA: ENSG00000178172
COSMIC: SPINK6
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000178172 | ENST00000325630 | Q6UWN8 |
| ENSG00000178172 | ENST00000514389 | D6RGX9 |
| ENSG00000178172 | ENST00000621437 | Q6UWN8 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Developmental Biology | REACTOME | R-HSA-1266738 |
| Keratinization | REACTOME | R-HSA-6805567 |
| Formation of the cornified envelope | REACTOME | R-HSA-6809371 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34826211 | 2022 | SPINK6 inhibits human airway serine proteases and restricts influenza virus activation. | 6 |
| 34826211 | 2022 | SPINK6 inhibits human airway serine proteases and restricts influenza virus activation. | 6 |
| 34099859 | 2021 | Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium. | 2 |
| 34099859 | 2021 | Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium. | 2 |
| 27671677 | 2017 | SPINK6 Promotes Metastasis of Nasopharyngeal Carcinoma via Binding and Activation of Epithelial Growth Factor Receptor. | 33 |
| 27999203 | 2017 | Serine protease inhibitor kazal-type 6 inhibits tumorigenesis of human hepatocellular carcinoma cells via its extracellular action. | 6 |
| 27671677 | 2017 | SPINK6 Promotes Metastasis of Nasopharyngeal Carcinoma via Binding and Activation of Epithelial Growth Factor Receptor. | 33 |
| 27999203 | 2017 | Serine protease inhibitor kazal-type 6 inhibits tumorigenesis of human hepatocellular carcinoma cells via its extracellular action. | 6 |
| 26828269 | 2016 | The solution structure of the kallikrein-related peptidases inhibitor SPINK6. | 5 |
| 27354280 | 2016 | Gingipains of Porphyromonas gingivalis Affect the Stability and Function of Serine Protease Inhibitor of Kazal-type 6 (SPINK6), a Tissue Inhibitor of Human Kallikreins. | 8 |
| 26828269 | 2016 | The solution structure of the kallikrein-related peptidases inhibitor SPINK6. | 5 |
| 27354280 | 2016 | Gingipains of Porphyromonas gingivalis Affect the Stability and Function of Serine Protease Inhibitor of Kazal-type 6 (SPINK6), a Tissue Inhibitor of Human Kallikreins. | 8 |
| 24352040 | 2014 | Characterization of Spink6 in mouse skin: the conserved inhibitor of kallikrein-related peptidases is reduced by barrier injury. | 11 |
| 24352040 | 2014 | Characterization of Spink6 in mouse skin: the conserved inhibitor of kallikrein-related peptidases is reduced by barrier injury. | 11 |
| 23303447 | 2013 | Cross-linking of SPINK6 by transglutaminases protects from epidermal proteases. | 10 |
Citation
Dessen P
SPINK6 (serine peptidase inhibitor Kazal type 6)
Atlas Genet Cytogenet Oncol Haematol. 2017-10-01
Online version: http://atlasgeneticsoncology.org/gene/57134/spink6-(serine-peptidase-inhibitor-kazal-type-6)
