GSDME (gasdermin E)

2017-10-01  

Identity

HGNC
GSDME
LOCATION
7p15.3
LOCUSID
1687
ALIAS
DFNA5,ICERE-1

Other Information

Locus ID:

NCBI: 1687
MIM: 608798
HGNC: 2810
Ensembl: ENSG00000105928

Variants:

dbSNP: 1687
ClinVar: 1687
TCGA: ENSG00000105928
COSMIC: GSDME

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105928ENST00000342947O60443
ENSG00000105928ENST00000342947A0A024RA58
ENSG00000105928ENST00000409970O60443
ENSG00000105928ENST00000414428C9JSR4
ENSG00000105928ENST00000415480H7BZJ0
ENSG00000105928ENST00000419307O60443
ENSG00000105928ENST00000430096H7C0L2
ENSG00000105928ENST00000446822H7C147
ENSG00000105928ENST00000645220O60443
ENSG00000105928ENST00000645220A0A024RA58

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378643002024Novel, pathogenic insertion variant of GSDME associates with autosomal dominant hearing loss in a large Chinese pedigree.3
384292782024Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation.0
388526422024Insight into the structure, function and the tumor suppression effect of gasdermin E.0
378643002024Novel, pathogenic insertion variant of GSDME associates with autosomal dominant hearing loss in a large Chinese pedigree.3
384292782024Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation.0
388526422024Insight into the structure, function and the tumor suppression effect of gasdermin E.0
370859082023Gasdermin E regulates the stability and activation of EGFR in human non-small cell lung cancer cells.1
374389792023AMIGO2 attenuates innate cisplatin sensitivity by suppression of GSDME-conferred pyroptosis in non-small cell lung cancer.3
370859082023Gasdermin E regulates the stability and activation of EGFR in human non-small cell lung cancer cells.1
374389792023AMIGO2 attenuates innate cisplatin sensitivity by suppression of GSDME-conferred pyroptosis in non-small cell lung cancer.3
344808352022Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor-Induced Caspase 3/Gasdermin E-Mediated Pyroptosis.35
345538452022Expression levels of caspase-3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancer.5
346666462022Lobaplatin Induces Pyroptosis in Cervical Cancer Cells via the Caspase-3/GSDME Pathway.17
350025202022Apoptin induces pyroptosis of colorectal cancer cells via the GSDME-dependent pathway.29
351489982022Increased IRF9-STAT2 Signaling Leads to Adaptive Resistance toward Targeted Therapy in Melanoma by Restraining GSDME-Dependent Pyroptosis.11

Citation

Dessen P

GSDME (gasdermin E)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57150/gsdme-(gasdermin-e)