CEP72 (centrosomal protein 72)

2017-10-01  

Identity

HGNC
LOCATION
5p15.33
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 55722
MIM: 616475
HGNC: 25547
Ensembl: ENSG00000112877

Variants:

dbSNP: 55722
ClinVar: 55722
TCGA: ENSG00000112877
COSMIC: CEP72

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112877ENST00000264935Q9P209

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseClinicalAnnotationassociatedPD
PA451879vincristineChemicalClinicalAnnotation, MultilinkAnnotationassociatedPD25999454

References

Pubmed IDYearTitleCitations
257106582015Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia.53
195361352009Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formation.31
266186582016Lack of association of the CEP72 rs924607 TT genotype with vincristine-related peripheral neuropathy during the early phase of pediatric acute lymphoblastic leukemia treatment in a Spanish population.11
276182502017An Inherited Genetic Variant in CEP72 Promoter Predisposes to Vincristine-Induced Peripheral Neuropathy in Adults With Acute Lymphoblastic Leukemia.11
200907712010Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis.9
263000012016The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability.7
295178602018CEP72-ROS1: A novel ROS1 oncogenic fusion variant in lung adenocarcinoma identified by next-generation sequencing.4
301191322018Genetic polymorphisms in candidate genes are not associated with increased vincristine-related peripheral neuropathy in Arab children treated for acute childhood leukemia: a single institution study.3
309536032019Overexpression of CEP72 Promotes Bladder Urothelial Carcinoma Cell Aggressiveness via Epigenetic CREB-Mediated Induction of SERPINE1.1

Citation

Dessen P

CEP72 (centrosomal protein 72)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57154/cep72-(centrosomal-protein-72)