Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 107
MIM: 103072
HGNC: 232
Ensembl: ENSG00000164742
Variants:
dbSNP: 107
ClinVar: 107
TCGA: ENSG00000164742
COSMIC: ADCY1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000164742 | ENST00000297323 | Q08828 |
| ENSG00000164742 | ENST00000432715 | C9J1J0 |
| ENSG00000164742 | ENST00000621543 | C9J1J0 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA172 | GNAI1 | Gene | Pathway | associated | 19741567 | ||
| PA173 | GNAI3 | Gene | Pathway | associated | 19741567 | ||
| PA175 | GNAS | Gene | Pathway | associated | 19741567 | ||
| PA24347 | GNAI2 | Gene | Pathway | associated | 19741567 | ||
| PA447199 | Bipolar Disorder | Disease | ClinicalAnnotation | associated | PD | 29121268 | |
| PA450243 | lithium | Chemical | ClinicalAnnotation | associated | PD | 29121268 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36913138 | 2023 | Downregulated INHBB in endometrial tissue of recurrent implantation failure patients impeded decidualization through the ADCY1/cAMP signalling pathway. | 0 |
| 36913138 | 2023 | Downregulated INHBB in endometrial tissue of recurrent implantation failure patients impeded decidualization through the ADCY1/cAMP signalling pathway. | 0 |
| 35076816 | 2022 | Circ-LTBP1 is involved in doxorubicin-induced intracellular toxicity in cardiomyocytes via miR-107/ADCY1 signal. | 4 |
| 35076816 | 2022 | Circ-LTBP1 is involved in doxorubicin-induced intracellular toxicity in cardiomyocytes via miR-107/ADCY1 signal. | 4 |
| 34512170 | 2021 | Pancreatic cancer-derived exosomal microRNA-19a induces β-cell dysfunction by targeting ADCY1 and EPAC2. | 9 |
| 34650124 | 2021 | GNG7 and ADCY1 as diagnostic and prognostic biomarkers for pancreatic adenocarcinoma through bioinformatic-based analyses. | 7 |
| 34512170 | 2021 | Pancreatic cancer-derived exosomal microRNA-19a induces β-cell dysfunction by targeting ADCY1 and EPAC2. | 9 |
| 34650124 | 2021 | GNG7 and ADCY1 as diagnostic and prognostic biomarkers for pancreatic adenocarcinoma through bioinformatic-based analyses. | 7 |
| 30867808 | 2019 | MicroRNA-23a-3p Inhibits Mucosal Melanoma Growth and Progression through Targeting Adenylate Cyclase 1 and Attenuating cAMP and MAPK Pathways. | 36 |
| 30867808 | 2019 | MicroRNA-23a-3p Inhibits Mucosal Melanoma Growth and Progression through Targeting Adenylate Cyclase 1 and Attenuating cAMP and MAPK Pathways. | 36 |
| 28122154 | 2017 | Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitor. | 7 |
| 28223412 | 2017 | Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. | 29 |
| 28122154 | 2017 | Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitor. | 7 |
| 28223412 | 2017 | Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. | 29 |
| 25462816 | 2015 | Membranous adenylyl cyclase 1 activation is regulated by oxidation of N- and C-terminal methionine residues in calmodulin. | 7 |
Citation
Dessen P
ADCY1 (adenylate cyclase 1)
Atlas Genet Cytogenet Oncol Haematol. 2017-10-01
Online version: http://atlasgeneticsoncology.org/gene/57160/adcy1-(adenylate-cyclase-1)
