FNDC4 (fibronectin type III domain containing 4)

2017-10-01  

Identity

HGNC
FNDC4
LOCATION
2p23.3
LOCUSID
64838
ALIAS
FRCP1

Other Information

Locus ID:

NCBI: 64838
MIM: 611905
HGNC: 20239
Ensembl: ENSG00000115226

Variants:

dbSNP: 64838
ClinVar: 64838
TCGA: ENSG00000115226
COSMIC: FNDC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115226ENST00000264703Q9H6D8

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381815852024FNDC4 reduces inflammation, proliferation, invasion and migration of rheumatoid synovial cells by inhibiting CCL2/ERK signaling.0
381815852024FNDC4 reduces inflammation, proliferation, invasion and migration of rheumatoid synovial cells by inhibiting CCL2/ERK signaling.0
355219002022Irisin and the fibronectin type III domain-containing family: structure, signaling and role in female reproduction.4
355219002022Irisin and the fibronectin type III domain-containing family: structure, signaling and role in female reproduction.4
340169662021Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.17
344658842021FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes.28
340169662021Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.17
344658842021FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes.28
324077262020FNDC4, a novel adipokine that reduces lipogenesis and promotes fat browning in human visceral adipocytes.23
324077262020FNDC4, a novel adipokine that reduces lipogenesis and promotes fat browning in human visceral adipocytes.23
270669072016FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice.40
270669072016FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice.40
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105

Citation

Dessen P

FNDC4 (fibronectin type III domain containing 4)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57161/fndc4-(fibronectin-type-iii-domain-containing-4)