Identity
HGNC
LOCATION
11p15.5
LOCUSID
ALIAS
AVR,CLR11.4,NALP6,NAVR,NAVR/AVR,PAN3,PYPAF5
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 171389
MIM: 609650
HGNC: 22944
Ensembl: ENSG00000174885
Variants:
dbSNP: 171389
ClinVar: 171389
TCGA: ENSG00000174885
COSMIC: NLRP6
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000174885 | ENST00000312165 | P59044 |
| ENSG00000174885 | ENST00000534750 | P59044 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| NOD-like receptor signaling pathway | KEGG | ko04621 |
| NOD-like receptor signaling pathway | KEGG | hsa04621 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38278335 | 2024 | NLRP6 deficiency suppresses colorectal cancer liver metastasis growth by modulating M-MDSC-induced immunosuppressive microenvironment. | 1 |
| 38315242 | 2024 | Decreased expression of the NLRP6 inflammasome is associated with increased intestinal permeability and inflammation in obesity with type 2 diabetes. | 1 |
| 38720893 | 2024 | NLRP6 negatively regulates host defense against polymicrobial sepsis. | 0 |
| 38278335 | 2024 | NLRP6 deficiency suppresses colorectal cancer liver metastasis growth by modulating M-MDSC-induced immunosuppressive microenvironment. | 1 |
| 38315242 | 2024 | Decreased expression of the NLRP6 inflammasome is associated with increased intestinal permeability and inflammation in obesity with type 2 diabetes. | 1 |
| 38720893 | 2024 | NLRP6 negatively regulates host defense against polymicrobial sepsis. | 0 |
| 35651286 | 2023 | A novel pyroptosis risk model composed of NLRP6 effectively predicts the prognosis of hepatocellular carcinoma patients. | 6 |
| 37770465 | 2023 | NLRP6 potentiates PI3K/AKT signalling by promoting autophagic degradation of p85α to drive tumorigenesis. | 1 |
| 35651286 | 2023 | A novel pyroptosis risk model composed of NLRP6 effectively predicts the prognosis of hepatocellular carcinoma patients. | 6 |
| 37770465 | 2023 | NLRP6 potentiates PI3K/AKT signalling by promoting autophagic degradation of p85α to drive tumorigenesis. | 1 |
| 34942528 | 2022 | A detrimental role of NLRP6 in host iron metabolism during Salmonella infection. | 4 |
| 35068231 | 2022 | NLRP3 and NLRP6 expression in pterygium and normal conjunctiva and their relationship with pterygium formation and recurrence. | 1 |
| 35093492 | 2022 | Defects in NLRP6, autophagy and goblet cell homeostasis are associated with reduced duodenal CRH receptor 2 expression in patients with functional dyspepsia. | 6 |
| 35650327 | 2022 | Physiological and pathophysiological functions of NLRP6: pro- and anti-inflammatory roles. | 10 |
| 34942528 | 2022 | A detrimental role of NLRP6 in host iron metabolism during Salmonella infection. | 4 |
Citation
Dessen P
NLRP6 (NLR family pyrin domain containing 6)
Atlas Genet Cytogenet Oncol Haematol. 2017-10-01
Online version: http://atlasgeneticsoncology.org/gene/57174/
