RANGAP1 (Ran GTPase activating protein 1)

2017-10-01  

Identity

HGNC
LOCATION
22q13.2
LOCUSID
ALIAS
Fug1,RANGAP,SD
FUSION GENES

Other Information

Locus ID:

NCBI: 5905
MIM: 602362
HGNC: 9854
Ensembl: ENSG00000100401

Variants:

dbSNP: 5905
ClinVar: 5905
TCGA: ENSG00000100401
COSMIC: RANGAP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100401ENST00000356244P46060
ENSG00000100401ENST00000356244A0A024R1U0
ENSG00000100401ENST00000405486P46060
ENSG00000100401ENST00000405486A0A024R1U0
ENSG00000100401ENST00000418067B0QYT5
ENSG00000100401ENST00000422838B0QYT6
ENSG00000100401ENST00000446258H0Y4Q3
ENSG00000100401ENST00000452543B0QYT4
ENSG00000100401ENST00000455915P46060
ENSG00000100401ENST00000455915A0A024R1U0

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Nuclear pore complexKEGGhsa_M00427
Nuclear pore complexKEGGM00427
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Rev-mediated nuclear export of HIV RNAREACTOMER-HSA-165054
Host Interactions of HIV factorsREACTOMER-HSA-162909
Interactions of Rev with host cellular proteinsREACTOMER-HSA-177243
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
SUMOylation of DNA replication proteinsREACTOMER-HSA-4615885

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
378455852024Hepatitis B virus core protein stabilizes RANGAP1 to upregulate KDM2A and facilitate hepatocarcinogenesis.1
378455852024Hepatitis B virus core protein stabilizes RANGAP1 to upregulate KDM2A and facilitate hepatocarcinogenesis.1
366969032023Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma.6
369165342023SUMOylation mediates the disassembly of the Smad4 nuclear export complex via RanGAP1 in KELOIDS.3
366969032023Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma.6
369165342023SUMOylation mediates the disassembly of the Smad4 nuclear export complex via RanGAP1 in KELOIDS.3
336495382021The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis.8
346112292021CircRNA_0079586 and circRNA_RanGAP1 are involved in the pathogenesis of intracranial aneurysms rupture by regulating the expression of MPO.5
336495382021The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis.8
346112292021CircRNA_0079586 and circRNA_RanGAP1 are involved in the pathogenesis of intracranial aneurysms rupture by regulating the expression of MPO.5
318119092020Circular RNA circ-RanGAP1 regulates VEGFA expression by targeting miR-877-3p to facilitate gastric cancer invasion and metastasis.130
318119092020Circular RNA circ-RanGAP1 regulates VEGFA expression by targeting miR-877-3p to facilitate gastric cancer invasion and metastasis.130
283844742017Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport.119
289000322017Nucleolar and spindle-associated protein 1 (NUSAP1) interacts with a SUMO E3 ligase complex during chromosome segregation.21
283844742017Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport.119

Citation

Dessen P

RANGAP1 (Ran GTPase activating protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57188/rangap1-(ran-gtpase-activating-protein-1)