HTN1 (histatin 1)

2017-10-01  

Identity

HGNC
LOCATION
4q13.3
LOCUSID
ALIAS
HIS1
FUSION GENES

Other Information

Locus ID:

NCBI: 3346
MIM: 142701
HGNC: 5283
Ensembl: ENSG00000126550

Variants:

dbSNP: 3346
ClinVar: 3346
TCGA: ENSG00000126550
COSMIC: HTN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126550ENST00000246896P15515
ENSG00000126550ENST00000511674P15515
ENSG00000126550ENST00000610341P15515

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Antimicrobial peptidesREACTOMER-HSA-6803157

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
354897302022Association Between PD-L1 and Histatin1, 3 Expression in Advanced Head and Neck Squamous Cell Carcinoma.0
359708442022GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting and -activating properties of human salivary histatin 1.2
354897302022Association Between PD-L1 and Histatin1, 3 Expression in Advanced Head and Neck Squamous Cell Carcinoma.0
359708442022GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting and -activating properties of human salivary histatin 1.2
342330612021Histatin-1 is an endogenous ligand of the sigma-2 receptor.4
342330612021Histatin-1 is an endogenous ligand of the sigma-2 receptor.4
322250062020Salivary Histatin 1 and 2 Are Targeted to Mitochondria and Endoplasmic Reticulum in Human Cells.7
324845862020Human salivary histatin-1 (Hst1) promotes bone morphogenetic protein 2 (BMP2)-induced osteogenesis and angiogenesis.11
322250062020Salivary Histatin 1 and 2 Are Targeted to Mitochondria and Endoplasmic Reticulum in Human Cells.7
324845862020Human salivary histatin-1 (Hst1) promotes bone morphogenetic protein 2 (BMP2)-induced osteogenesis and angiogenesis.11
313119932019Presence of Histatin-1 in Human Tears and Association with Aqueous Deficient Dry Eye Diagnosis: A Preliminary Study.14
313119932019Presence of Histatin-1 in Human Tears and Association with Aqueous Deficient Dry Eye Diagnosis: A Preliminary Study.14
301381052018Salivary peptide histatin 1 mediated cell adhesion: a possible role in mesenchymal-epithelial transition and in pathologies.4
301381052018Salivary peptide histatin 1 mediated cell adhesion: a possible role in mesenchymal-epithelial transition and in pathologies.4
285225952017Human salivary peptide histatin-1 stimulates epithelial and endothelial cell adhesion and barrier function.14

Citation

Dessen P

HTN1 (histatin 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57190/htn1-(histatin-1)