MGRN1 (mahogunin ring finger 1)

2017-10-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
RNF156
FUSION GENES

Other Information

Locus ID:

NCBI: 23295
MIM: 607559
HGNC: 20254
Ensembl: ENSG00000102858

Variants:

dbSNP: 23295
ClinVar: 23295
TCGA: ENSG00000102858
COSMIC: MGRN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102858ENST00000262370O60291
ENSG00000102858ENST00000399577O60291
ENSG00000102858ENST00000415496O60291
ENSG00000102858ENST00000536343B4DR12
ENSG00000102858ENST00000586183O60291
ENSG00000102858ENST00000587747K7EPJ5
ENSG00000102858ENST00000588994O60291
ENSG00000102858ENST00000590790K7EIM7
ENSG00000102858ENST00000591895K7ERA1
ENSG00000102858ENST00000593224K7EJN3

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380083932024MGRN1 depletion promotes intercellular adhesion in melanoma by upregulation of E-cadherin and inhibition of CDC42.0
380083932024MGRN1 depletion promotes intercellular adhesion in melanoma by upregulation of E-cadherin and inhibition of CDC42.0
349216352021Mahogunin Ring Finger 1 regulates pigmentation by controlling the pH of melanosomes in melanocytes and melanoma cells.4
349216352021Mahogunin Ring Finger 1 regulates pigmentation by controlling the pH of melanosomes in melanocytes and melanoma cells.4
289473862018Human melanocortin 1 receptor-mediated ubiquitination of nonvisual arrestins. Role of Mahogunin Ring Finger 1 E3 ligase.5
289473862018Human melanocortin 1 receptor-mediated ubiquitination of nonvisual arrestins. Role of Mahogunin Ring Finger 1 E3 ligase.5
284758712017Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival.10
289024522017MGRN1-mediated ubiquitination of α-tubulin regulates microtubule dynamics and intracellular transport.13
284758712017Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival.10
289024522017MGRN1-mediated ubiquitination of α-tubulin regulates microtubule dynamics and intracellular transport.13
267430862016Ubiquitin-mediated regulation of the E3 ligase GP78 by MGRN1 in trans affects mitochondrial homeostasis.23
275770812016DNA methylation array analysis identifies breast cancer associated RPTOR, MGRN1 and RAPSN hypomethylation in peripheral blood DNA.18
277130962016Regulation of Mitofusin1 by Mahogunin Ring Finger-1 and the proteasome modulates mitochondrial fusion.16
267430862016Ubiquitin-mediated regulation of the E3 ligase GP78 by MGRN1 in trans affects mitochondrial homeostasis.23
275770812016DNA methylation array analysis identifies breast cancer associated RPTOR, MGRN1 and RAPSN hypomethylation in peripheral blood DNA.18

Citation

Dessen P

MGRN1 (mahogunin ring finger 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57206/mgrn1-(mahogunin-ring-finger-1)