MRPS27 (mitochondrial ribosomal protein S27)

2017-10-01  

Identity

HGNC
MRPS27
LOCATION
5q13.2
LOCUSID
23107
ALIAS
MRP-S27,S27mt
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23107
MIM: 611989
HGNC: 14512
Ensembl: ENSG00000113048

Variants:

dbSNP: 23107
ClinVar: 23107
TCGA: ENSG00000113048
COSMIC: MRPS27

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113048ENST00000261413Q92552
ENSG00000113048ENST00000261413A0A024RAJ1
ENSG00000113048ENST00000457646G5EA06
ENSG00000113048ENST00000508863D6RH20
ENSG00000113048ENST00000513900Q92552
ENSG00000113048ENST00000515404D6RJC7
ENSG00000113048ENST00000522095E5RJ73

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial translationREACTOMER-HSA-5368287
Mitochondrial translation initiationREACTOMER-HSA-5368286
Mitochondrial translation elongationREACTOMER-HSA-5389840
Mitochondrial translation terminationREACTOMER-HSA-5419276

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376035332023The value of RPS15 and MRPS27 in ischemic stroke.1
376035332023The value of RPS15 and MRPS27 in ischemic stroke.1
287143662017High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes.15
287143662017High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes.15
228417152012MRPS27 is a pentatricopeptide repeat domain protein required for the translation of mitochondrially encoded proteins.27
228417152012MRPS27 is a pentatricopeptide repeat domain protein required for the translation of mitochondrially encoded proteins.27
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20

Citation

Dessen P

MRPS27 (mitochondrial ribosomal protein S27)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57220/gene-fusions-explorer/meetings/