ASB3 (ankyrin repeat and SOCS box containing 3)

2017-11-01  

Identity

HGNC
LOCATION
2p16.2
LOCUSID
ALIAS
ASB-3
FUSION GENES

Other Information

Locus ID:

NCBI: 51130
MIM: 605760
HGNC: 16013
Ensembl: ENSG00000115239

Variants:

dbSNP: 51130
ClinVar: 51130
TCGA: ENSG00000115239
COSMIC: ASB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115239ENST00000263634Q9Y575
ENSG00000115239ENST00000394717Q9Y575
ENSG00000115239ENST00000406053H7BYZ6
ENSG00000115239ENST00000406625Q9Y575
ENSG00000115239ENST00000406687Q9Y575

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
383344502024ASB3 promotes hepatocellular carcinoma progression by mediating DR5 ubiquitination in TRAIL resistance.0
383344502024ASB3 promotes hepatocellular carcinoma progression by mediating DR5 ubiquitination in TRAIL resistance.0
280882282017The loss-of-function mutations and down-regulated expression of ASB3 gene promote the growth and metastasis of colorectal cancer cells.12
280882282017The loss-of-function mutations and down-regulated expression of ASB3 gene promote the growth and metastasis of colorectal cancer cells.12
255621072015Genome-wide association study of short-acting β2-agonists. A novel genome-wide significant locus on chromosome 2 near ASB3.21
255621072015Genome-wide association study of short-acting β2-agonists. A novel genome-wide significant locus on chromosome 2 near ASB3.21
158998732005Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II.33
158998732005Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II.33

Citation

Dessen P

ASB3 (ankyrin repeat and SOCS box containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2017-11-01

Online version: http://atlasgeneticsoncology.org/gene/57260/asb3-(ankyrin-repeat-and-socs-box-containing-3)