Identity
HGNC
LOCATION
3q22.3
LOCUSID
ALIAS
MSL-2,MSL2L1,RNF184
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55167
MIM: 614802
HGNC: 25544
Ensembl: ENSG00000174579
Variants:
dbSNP: 55167
ClinVar: 55167
TCGA: ENSG00000174579
COSMIC: MSL2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Chromatin organization | REACTOME | R-HSA-4839726 |
| Chromatin modifying enzymes | REACTOME | R-HSA-3247509 |
| HATs acetylate histones | REACTOME | R-HSA-3214847 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38702431 | 2024 | Novel protein-truncating variants of a chromatin-modifying gene MSL2 in syndromic neurodevelopmental disorders. | 1 |
| 38702431 | 2024 | Novel protein-truncating variants of a chromatin-modifying gene MSL2 in syndromic neurodevelopmental disorders. | 1 |
| 30362606 | 2019 | The long noncoding RNA MALAT-1 functions as a competing endogenous RNA to regulate MSL2 expression by sponging miR-338-3p in myasthenia gravis. | 19 |
| 30362606 | 2019 | The long noncoding RNA MALAT-1 functions as a competing endogenous RNA to regulate MSL2 expression by sponging miR-338-3p in myasthenia gravis. | 19 |
| 28608964 | 2017 | Hepatitis B virus X protein-elevated MSL2 modulates hepatitis B virus covalently closed circular DNA by inducing degradation of APOBEC3B to enhance hepatocarcinogenesis. | 40 |
| 28608964 | 2017 | Hepatitis B virus X protein-elevated MSL2 modulates hepatitis B virus covalently closed circular DNA by inducing degradation of APOBEC3B to enhance hepatocarcinogenesis. | 40 |
| 23874665 | 2013 | Msl2 is a novel component of the vertebrate DNA damage response. | 3 |
| 23874665 | 2013 | Msl2 is a novel component of the vertebrate DNA damage response. | 3 |
| 21726816 | 2011 | The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. | 74 |
| 21726816 | 2011 | The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. | 74 |
| 16227571 | 2005 | A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. | 170 |
| 16227571 | 2005 | A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. | 170 |
Citation
Dessen P
MSL2 (MSL complex subunit 2)
Atlas Genet Cytogenet Oncol Haematol. 2017-11-01
Online version: http://atlasgeneticsoncology.org/gene/57261/msl2-(msl-complex-subunit-2)
