ZBTB46 (zinc finger and BTB domain containing 46)

2018-02-01  

Identity

HGNC
ZBTB46
LOCATION
20q13.33
LOCUSID
140685
ALIAS
BTBD4,BZEL,RINZF,ZNF340,dJ583P15.7,dJ583P15.8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 140685
MIM: 614639
HGNC: 16094
Ensembl: ENSG00000130584

Variants:

dbSNP: 140685
ClinVar: 140685
TCGA: ENSG00000130584
COSMIC: ZBTB46

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130584ENST00000245663Q86UZ6
ENSG00000130584ENST00000302995Q86UZ6
ENSG00000130584ENST00000395104Q86UZ6
ENSG00000130584ENST00000650966A0A494BZW5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
348155242022PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer.5
348155242022PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer.5
333980732021Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance.19
337235762021Single nucleotide variations in ZBTB46 are associated with post-thrombolytic parenchymal haematoma.6
333980732021Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance.19
337235762021Single nucleotide variations in ZBTB46 are associated with post-thrombolytic parenchymal haematoma.6
298849092019ZBTB46 is a shear-sensitive transcription factor inhibiting endothelial cell proliferation via gene expression regulation of cell cycle proteins.19
303127312019Androgen deprivation-induced ZBTB46-PTGS1 signaling promotes neuroendocrine differentiation of prostate cancer.19
298849092019ZBTB46 is a shear-sensitive transcription factor inhibiting endothelial cell proliferation via gene expression regulation of cell cycle proteins.19
303127312019Androgen deprivation-induced ZBTB46-PTGS1 signaling promotes neuroendocrine differentiation of prostate cancer.19
297436542018Expression of the transcription factor ZBTB46 distinguishes human histiocytic disorders of classical dendritic cell origin.6
297436542018Expression of the transcription factor ZBTB46 distinguishes human histiocytic disorders of classical dendritic cell origin.6
286920462017Inhibition of the androgen receptor induces a novel tumor promoter, ZBTB46, for prostate cancer metastasis.22
286920462017Inhibition of the androgen receptor induces a novel tumor promoter, ZBTB46, for prostate cancer metastasis.22
237399152013MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis.27

Citation

Dessen P

ZBTB46 (zinc finger and BTB domain containing 46)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57274/zbtb46-(zinc-finger-and-btb-domain-containing-46)