B4GALT4 (beta-1,4-galactosyltransferase 4)

2018-02-01  

Identity

HGNC
LOCATION
3q13.32
LOCUSID
ALIAS
B4Gal-T4,beta4Gal-T4
FUSION GENES

Other Information

Locus ID:

NCBI: 8702
MIM: 604015
HGNC: 927
Ensembl: ENSG00000121578

Variants:

dbSNP: 8702
ClinVar: 8702
TCGA: ENSG00000121578
COSMIC: B4GALT4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121578ENST00000359213O60513
ENSG00000121578ENST00000359213B2RAZ5
ENSG00000121578ENST00000393765O60513
ENSG00000121578ENST00000393765B2RAZ5
ENSG00000121578ENST00000467604C9J3R8
ENSG00000121578ENST00000470111C9JE00
ENSG00000121578ENST00000471675C9JA31
ENSG00000121578ENST00000473887C9JY38
ENSG00000121578ENST00000475803C9J4S5
ENSG00000121578ENST00000479150C9J5S0
ENSG00000121578ENST00000480814E7ETS9
ENSG00000121578ENST00000483209O60513
ENSG00000121578ENST00000483209B2RAZ5
ENSG00000121578ENST00000491906C9JY35
ENSG00000121578ENST00000493932C9J644

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Glycosaminoglycan biosynthesis - keratan sulfateKEGGko00533
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGko00601
Glycosaminoglycan biosynthesis - keratan sulfateKEGGhsa00533
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGhsa00601
Metabolic pathwaysKEGGhsa01100
Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4CerKEGGhsa_M00071
Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4CerKEGGM00071
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
N-glycan antennae elongation in the medial/trans-GolgiREACTOMER-HSA-975576
N-Glycan antennae elongationREACTOMER-HSA-975577
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Keratan sulfate/keratin metabolismREACTOMER-HSA-1638074
Keratan sulfate biosynthesisREACTOMER-HSA-2022854

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
342700952022The critical role of B4GALT4 in promoting microtubule spindle assembly in HCC through the regulation of PLK1 and RHAMM expression.6
342700952022The critical role of B4GALT4 in promoting microtubule spindle assembly in HCC through the regulation of PLK1 and RHAMM expression.6
328272912020N-glycosylation of the human β1,4-galactosyltransferase 4 is crucial for its activity and Golgi localization.6
328272912020N-glycosylation of the human β1,4-galactosyltransferase 4 is crucial for its activity and Golgi localization.6
282286162017Transcriptional Mechanism of the β4-Galactosyltransferase 4 Gene in SW480 Human Colon Cancer Cell Line.2
282286162017Transcriptional Mechanism of the β4-Galactosyltransferase 4 Gene in SW480 Human Colon Cancer Cell Line.2

Citation

Dessen P

B4GALT4 (beta-1,4-galactosyltransferase 4)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57298/b4galt4-(beta-1-4-galactosyltransferase-4)