Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 57393
MIM: 300631
HGNC: 29437
Ensembl: ENSG00000147003
Variants:
dbSNP: 57393
ClinVar: 57393
TCGA: ENSG00000147003
COSMIC: CLTRN
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000147003 | ENST00000380342 | Q9HBJ8 |
| ENSG00000147003 | ENST00000650271 | A0A3B3ITM8 |
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism of proteins | REACTOME | R-HSA-392499 |
| Peptide hormone metabolism | REACTOME | R-HSA-2980736 |
| Insulin processing | REACTOME | R-HSA-264876 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36264884 | 2023 | Collectrin (Tmem27) deficiency in proximal tubules causes hypertension in mice and a TMEM27 variant associates with blood pressure in males in a Latino cohort. | 3 |
| 36264884 | 2023 | Collectrin (Tmem27) deficiency in proximal tubules causes hypertension in mice and a TMEM27 variant associates with blood pressure in males in a Latino cohort. | 3 |
| 36369873 | 2022 | TMEM27 expression and clinical characteristics and survival in clear cell renal cell carcinoma. | 0 |
| 36369873 | 2022 | TMEM27 expression and clinical characteristics and survival in clear cell renal cell carcinoma. | 0 |
| 28764560 | 2018 | Serum collectrin levels in patients with early- and late-onset preeclampsia. | 1 |
| 28764560 | 2018 | Serum collectrin levels in patients with early- and late-onset preeclampsia. | 1 |
| 27417314 | 2016 | Lack of TMEM27 expression is associated with postoperative progression of clinically localized conventional renal cell carcinoma. | 3 |
| 27417314 | 2016 | Lack of TMEM27 expression is associated with postoperative progression of clinically localized conventional renal cell carcinoma. | 3 |
| 24693993 | 2014 | Tmem27 is upregulated by vitamin D in INS-1 cells and its serum concentrations are low in patients with autoimmune diabetes. | 1 |
| 24693993 | 2014 | Tmem27 is upregulated by vitamin D in INS-1 cells and its serum concentrations are low in patients with autoimmune diabetes. | 1 |
| 22628310 | 2012 | Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2. | 9 |
| 22628310 | 2012 | Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2. | 9 |
| 21814048 | 2011 | Collectrin and ACE2 in renal and intestinal amino acid transport. | 34 |
| 21907142 | 2011 | Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass. | 59 |
| 21814048 | 2011 | Collectrin and ACE2 in renal and intestinal amino acid transport. | 34 |
Citation
Dessen P
CLTRN (collectrin, amino acid transport regulator)
Atlas Genet Cytogenet Oncol Haematol. 2018-02-01
Online version: http://atlasgeneticsoncology.org/gene/57309/chromosome-explorer/new-content/
