ATP5F1A (ATP synthase F1 subunit alpha)

2018-02-01  

Identity

HGNC
LOCATION
18q21.1
LOCUSID
ALIAS
ATP5A,ATP5A1,ATP5AL2,ATPM,COXPD22,HEL-S-123m,MC5DN4,MOM2,OMR,ORM,hATP1

Other Information

Locus ID:

NCBI: 498
MIM: 164360
HGNC: 823
Ensembl: ENSG00000152234

Variants:

dbSNP: 498
ClinVar: 498
TCGA: ENSG00000152234
COSMIC: ATP5F1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152234ENST00000282050P25705
ENSG00000152234ENST00000282050V9HW26
ENSG00000152234ENST00000398752P25705
ENSG00000152234ENST00000398752V9HW26
ENSG00000152234ENST00000585650K7EQU6
ENSG00000152234ENST00000586592A0A0A0MTS3
ENSG00000152234ENST00000589252K7ENJ4
ENSG00000152234ENST00000589869K7EK77
ENSG00000152234ENST00000590156K7EM08
ENSG00000152234ENST00000590324K7EJP1
ENSG00000152234ENST00000590406K7ERX7
ENSG00000152234ENST00000590665P25705
ENSG00000152234ENST00000591981K7EKV9
ENSG00000152234ENST00000592364K7ESA0
ENSG00000152234ENST00000592989K7EQH4
ENSG00000152234ENST00000593152P25705

Pathways

PathwaySourceExternal ID
Oxidative phosphorylationKEGGko00190
Alzheimer's diseaseKEGGko05010
Huntington's diseaseKEGGko05016
Oxidative phosphorylationKEGGhsa00190
Alzheimer's diseaseKEGGhsa05010
Parkinson's diseaseKEGGhsa05012
Huntington's diseaseKEGGhsa05016
Metabolic pathwaysKEGGhsa01100
F-type ATPase, eukaryotesKEGGhsa_M00158
F-type ATPase, eukaryotesKEGGM00158
Metabolism of proteinsREACTOMER-HSA-392499
Mitochondrial protein importREACTOMER-HSA-1268020
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Formation of ATP by chemiosmotic couplingREACTOMER-HSA-163210

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
389782252024BRG1 promotes liver cancer cell proliferation and metastasis by enhancing mitochondrial function and ATP5A1 synthesis through TOMM40.0
389782252024BRG1 promotes liver cancer cell proliferation and metastasis by enhancing mitochondrial function and ATP5A1 synthesis through TOMM40.0
365113432023Growth arrest and DNA damage-inducible alpha regulates muscle repair and fat infiltration through ATP synthase F1 subunit alpha.5
366406592023Meta-analysis of brain samples of individuals with schizophrenia detects down-regulation of multiple ATP synthase encoding genes in both females and males.4
380169972023Proteomic analyses identify HK1 and ATP5A to be overexpressed in distant metastases of lung adenocarcinomas compared to matched primary tumors.0
365113432023Growth arrest and DNA damage-inducible alpha regulates muscle repair and fat infiltration through ATP synthase F1 subunit alpha.5
366406592023Meta-analysis of brain samples of individuals with schizophrenia detects down-regulation of multiple ATP synthase encoding genes in both females and males.4
380169972023Proteomic analyses identify HK1 and ATP5A to be overexpressed in distant metastases of lung adenocarcinomas compared to matched primary tumors.0
343766792021Defining the molecular mechanisms of the mitochondrial permeability transition through genetic manipulation of F-ATP synthase.31
344833392021A recurrent de novo ATP5F1A substitution associated with neonatal complex V deficiency.2
345202922021ATP5A1 Participates in Transcriptional and Posttranscriptional Regulation of Cancer-Associated Genes by Modulating Their Expression and Alternative Splicing Profiles in HeLa Cells.7
343766792021Defining the molecular mechanisms of the mitochondrial permeability transition through genetic manipulation of F-ATP synthase.31
344833392021A recurrent de novo ATP5F1A substitution associated with neonatal complex V deficiency.2
345202922021ATP5A1 Participates in Transcriptional and Posttranscriptional Regulation of Cancer-Associated Genes by Modulating Their Expression and Alternative Splicing Profiles in HeLa Cells.7
320195492020F0F1 ATP synthase regulates extracellular calcium influx in human neutrophils by interacting with Ca(v)2.3 and modulates neutrophil accumulation in the lipopolysaccharide-challenged lung.2

Citation

Dessen P

ATP5F1A (ATP synthase F1 subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57314/atp5f1a-(atp-synthase-f1-subunit-alpha)