Identity
HGNC
LOCATION
3p22.3
LOCUSID
ALIAS
CKLFSF6,PRO2219
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 54918
MIM: 607889
HGNC: 19177
Ensembl: ENSG00000091317
Variants:
dbSNP: 54918
ClinVar: 54918
TCGA: ENSG00000091317
COSMIC: CMTM6
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000091317 | ENST00000205636 | Q9NX76 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Innate Immune System | REACTOME | R-HSA-168249 |
| Neutrophil degranulation | REACTOME | R-HSA-6798695 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38082156 | 2024 | From patient tissue correlates to molecular mechanisms of cancer immune evasion: the emerging role of CD58 and PD-L1 co-regulation via CMTM6. | 0 |
| 38113979 | 2024 | Bioinformatics analysis of CMTM family in pan-cancer and preliminary exploration of CMTM6 in bladder cancer. | 2 |
| 38165704 | 2024 | Transmembrane Protein CMTM6 Alleviates Ocular Inflammatory Response and Improves Corneal Epithelial Barrier Function in Experimental Dry Eye. | 1 |
| 38221563 | 2024 | CMTM 6 promotes the development of thyroid cancer by inhibiting NIS activity through activating the MAPK signaling pathway. | 0 |
| 38686653 | 2024 | Autophagy-related CMTM6 promotes glioblastoma progression by activating Wnt/β-catenin pathway and acts as an onco-immunological biomarker. | 0 |
| 38082156 | 2024 | From patient tissue correlates to molecular mechanisms of cancer immune evasion: the emerging role of CD58 and PD-L1 co-regulation via CMTM6. | 0 |
| 38113979 | 2024 | Bioinformatics analysis of CMTM family in pan-cancer and preliminary exploration of CMTM6 in bladder cancer. | 2 |
| 38165704 | 2024 | Transmembrane Protein CMTM6 Alleviates Ocular Inflammatory Response and Improves Corneal Epithelial Barrier Function in Experimental Dry Eye. | 1 |
| 38221563 | 2024 | CMTM 6 promotes the development of thyroid cancer by inhibiting NIS activity through activating the MAPK signaling pathway. | 0 |
| 38686653 | 2024 | Autophagy-related CMTM6 promotes glioblastoma progression by activating Wnt/β-catenin pathway and acts as an onco-immunological biomarker. | 0 |
| 36627608 | 2023 | CMTM6 overexpression confers trastuzumab resistance in HER2-positive breast cancer. | 8 |
| 36643629 | 2023 | CMTM6 is highly expressed in lung adenocarcinoma and can be used as a biomarker of a poor diagnosis. | 1 |
| 36815510 | 2023 | CMTM6 recruits T cells within the endocervical adenocarcinoma microenvironment and suppresses cell proliferation via the p53 pathway. | 2 |
| 36627608 | 2023 | CMTM6 overexpression confers trastuzumab resistance in HER2-positive breast cancer. | 8 |
| 36643629 | 2023 | CMTM6 is highly expressed in lung adenocarcinoma and can be used as a biomarker of a poor diagnosis. | 1 |
Citation
Dessen P
CMTM6 (CKLF like MARVEL transmembrane domain containing 6)
Atlas Genet Cytogenet Oncol Haematol. 2018-02-01
Online version: http://atlasgeneticsoncology.org/gene/57316/
