Identity
HGNC
LOCATION
1p22.3
LOCUSID
ALIAS
TRP-ML2,TRPML2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 255231
MIM: 607399
HGNC: 13357
Ensembl: ENSG00000153898
Variants:
dbSNP: 255231
ClinVar: 255231
TCGA: ENSG00000153898
COSMIC: MCOLN2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000153898 | ENST00000284027 | Q8IZK6 |
| ENSG00000153898 | ENST00000370608 | Q8IZK6 |
| ENSG00000153898 | ENST00000463065 | G5EA24 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35054871 | 2022 | Functional In Vitro Assessment of VEGFA/NOTCH2 Signaling Pathway and pRB Proteasomal Degradation and the Clinical Relevance of Mucolipin TRPML2 Overexpression in Glioblastoma Patients. | 4 |
| 35054871 | 2022 | Functional In Vitro Assessment of VEGFA/NOTCH2 Signaling Pathway and pRB Proteasomal Degradation and the Clinical Relevance of Mucolipin TRPML2 Overexpression in Glioblastoma Patients. | 4 |
| 34548638 | 2021 | Endolysosomal ion channel MCOLN2 (Mucolipin-2) promotes prostate cancer progression via IL-1β/NF-κB pathway. | 9 |
| 34548638 | 2021 | Endolysosomal ion channel MCOLN2 (Mucolipin-2) promotes prostate cancer progression via IL-1β/NF-κB pathway. | 9 |
| 31178222 | 2019 | Structure of the Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain. | 8 |
| 31178222 | 2019 | Structure of the Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain. | 8 |
| 29382735 | 2018 | Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses. | 25 |
| 29382735 | 2018 | Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses. | 25 |
| 27248469 | 2016 | Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: role in tumor growth and progression. | 36 |
| 27248469 | 2016 | Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: role in tumor growth and progression. | 36 |
| 25445271 | 2015 | PAX5 is the transcriptional activator of mucolipin-2 (MCOLN2) gene. | 14 |
| 25445271 | 2015 | PAX5 is the transcriptional activator of mucolipin-2 (MCOLN2) gene. | 14 |
| 22753890 | 2012 | Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules. | 17 |
| 22753890 | 2012 | Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules. | 17 |
| 19885840 | 2010 | Functional multimerization of mucolipin channel proteins. | 28 |
Citation
Dessen P
MCOLN2 (mucolipin TRP cation channel 2)
Atlas Genet Cytogenet Oncol Haematol. 2018-02-01
Online version: http://atlasgeneticsoncology.org/gene/57328/mcoln2-(mucolipin-trp-cation-channel-2)
