TAC4 (tachykinin precursor 4)

2018-02-01  

Identity

HGNC
LOCATION
17q21.33
LOCUSID
ALIAS
EK,HK-1,HK1,PPT-C
FUSION GENES

Other Information

Locus ID:

NCBI: 255061
MIM: 607833
HGNC: 16641
Ensembl: ENSG00000176358

Variants:

dbSNP: 255061
ClinVar: 255061
TCGA: ENSG00000176358
COSMIC: TAC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176358ENST00000326219Q86UU9
ENSG00000176358ENST00000334568Q86UU9
ENSG00000176358ENST00000352793Q86UU9
ENSG00000176358ENST00000398154Q86UU9
ENSG00000176358ENST00000436235Q86UU9
ENSG00000176358ENST00000503603D6RAS6

Expression (GTEx)

0
1
2
3
4
5
6
7

References

Pubmed IDYearTitleCitations
340907872021Serum level of hemokinin-1 is significantly lower in patients with chronic spontaneous urticaria than in healthy subjects.1
340907872021Serum level of hemokinin-1 is significantly lower in patients with chronic spontaneous urticaria than in healthy subjects.1
326006682020Hemokinin-1 and substance P stimulate production of inflammatory cytokines and chemokines in human colonic mucosa via both NK(1) and NK(2) tachykinin receptors.4
326006682020Hemokinin-1 and substance P stimulate production of inflammatory cytokines and chemokines in human colonic mucosa via both NK(1) and NK(2) tachykinin receptors.4
271460342016Expression of Tachykinins and Tachykinin Receptors and Interaction with Kisspeptin in Human Granulosa and Cumulus Cells.7
274565492016Altered expression of the tachykinins substance P/neurokinin A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors in uterine leiomyomata.7
274580612016Human hemokinin-1 promotes migration of melanoma cells and increases MMP-2 and MT1-MMP expression by activating tumor cell NK1 receptors.5
271460342016Expression of Tachykinins and Tachykinin Receptors and Interaction with Kisspeptin in Human Granulosa and Cumulus Cells.7
274565492016Altered expression of the tachykinins substance P/neurokinin A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors in uterine leiomyomata.7
274580612016Human hemokinin-1 promotes migration of melanoma cells and increases MMP-2 and MT1-MMP expression by activating tumor cell NK1 receptors.5
225545852012Hemokinins modulate endothelium function and promote angiogenesis through neurokinin-1 receptor.5
225545852012Hemokinins modulate endothelium function and promote angiogenesis through neurokinin-1 receptor.5
211683922011The N-terminal domain of human hemokinin-1 influences functional selectivity property for tachykinin receptor neurokinin-1.5
213423632011Distinct differences in tachykinin gene expression in ulcerative colitis, Crohn's disease and diverticular disease: a role for hemokinin-1?11
213682352011The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1β, IL-23, and TNF-like 1A expression by monocytes.48

Citation

Dessen P

TAC4 (tachykinin precursor 4)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57342/tac4-(tachykinin-precursor-4)