PVRIG (PVR related immunoglobulin domain containing)

2018-02-01  

Identity

HGNC
PVRIG
LOCATION
7q22.1
LOCUSID
79037
ALIAS
C7orf15,CD112R

Other Information

Locus ID:

NCBI: 79037
MIM: 617012
HGNC: 32190
Ensembl: ENSG00000213413

Variants:

dbSNP: 79037
ClinVar: 79037
TCGA: ENSG00000213413
COSMIC: PVRIG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213413ENST00000317271Q6DKI7

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
367880882023Nonredundant Upregulation of CD112R (PVRIG) and PD-1 on Cytotoxic T Lymphocytes Located in T Cell Nests of Colorectal Cancer.1
367880882023Nonredundant Upregulation of CD112R (PVRIG) and PD-1 on Cytotoxic T Lymphocytes Located in T Cell Nests of Colorectal Cancer.1
331479372021PVRIG is a novel natural killer cell immune checkpoint receptor in acute myeloid leukemia.11
332982472021Hitting the complexity of the TIGIT-CD96-CD112R-CD226 axis for next-generation cancer immunotherapy.25
339039742021COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade.11
331479372021PVRIG is a novel natural killer cell immune checkpoint receptor in acute myeloid leukemia.11
332982472021Hitting the complexity of the TIGIT-CD96-CD112R-CD226 axis for next-generation cancer immunotherapy.25
339039742021COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade.11
306590542019PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8(+) T-cell Function.84
306590542019PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8(+) T-cell Function.84
286234592017Blockade of CD112R and TIGIT signaling sensitizes human natural killer cell functions.84
286234592017Blockade of CD112R and TIGIT signaling sensitizes human natural killer cell functions.84
267557052016Identification of CD112R as a novel checkpoint for human T cells.111
267557052016Identification of CD112R as a novel checkpoint for human T cells.111

Citation

Dessen P

PVRIG (PVR related immunoglobulin domain containing)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57344/pvrig-(pvr-related-immunoglobulin-domain-containing)