Identity
HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
B5R.1,B5R1,B5R2,NQO3A2,humb5R2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51706
MIM: 608341
HGNC: 13397
Ensembl: ENSG00000159348
Variants:
dbSNP: 51706
ClinVar: 51706
TCGA: ENSG00000159348
COSMIC: CYB5R1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000159348 | ENST00000367249 | Q9UHQ9 |
| ENSG00000159348 | ENST00000446185 | H7C0R7 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10176 | rasburicase | Chemical | LabelAnnotation | associated | |||
| PA450125 | isosorbide dinitrate | Chemical | LabelAnnotation | associated | |||
| PA450126 | isosorbide mononitrate | Chemical | LabelAnnotation | associated | |||
| PA450475 | metoclopramide | Chemical | LabelAnnotation | associated | |||
| PA451103 | primaquine | Chemical | LabelAnnotation | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33011882 | 2021 | Microsomal reductase activity in patients with thyroid neoplasms. | 5 |
| 33321093 | 2021 | Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1. | 182 |
| 33011882 | 2021 | Microsomal reductase activity in patients with thyroid neoplasms. | 5 |
| 33321093 | 2021 | Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1. | 182 |
| 27120783 | 2016 | CYB5R1 links epithelial-mesenchymal transition and poor prognosis in colorectal cancer. | 13 |
| 27120783 | 2016 | CYB5R1 links epithelial-mesenchymal transition and poor prognosis in colorectal cancer. | 13 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | 20 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | 20 |
| 19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | 105 |
| 19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | 105 |
Citation
Dessen P
CYB5R1 (cytochrome b5 reductase 1)
Atlas Genet Cytogenet Oncol Haematol. 2018-02-01
Online version: http://atlasgeneticsoncology.org/gene/57352/cyb5r1-(cytochrome-b5-reductase-1)
