LARP4 (La ribonucleoprotein 4)

2018-02-01  

Identity

HGNC
LARP4
LOCATION
12q13.12
LOCUSID
113251
ALIAS
PP13296
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 113251
MIM: 618657
HGNC: 24320
Ensembl: ENSG00000161813

Variants:

dbSNP: 113251
ClinVar: 113251
TCGA: ENSG00000161813
COSMIC: LARP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161813ENST00000293618Q71RC2
ENSG00000161813ENST00000347328Q71RC2
ENSG00000161813ENST00000398473Q71RC2
ENSG00000161813ENST00000429001Q71RC2
ENSG00000161813ENST00000517559E5RHZ8
ENSG00000161813ENST00000518444Q71RC2
ENSG00000161813ENST00000518561Q96J85
ENSG00000161813ENST00000520064X6RLN4
ENSG00000161813ENST00000522085Q71RC2
ENSG00000161813ENST00000523389E5RJH8
ENSG00000161813ENST00000548174F8VNV1
ENSG00000161813ENST00000548697F8VXL0
ENSG00000161813ENST00000548993F8W1I4
ENSG00000161813ENST00000550260F8VY40
ENSG00000161813ENST00000550522F8VSA9
ENSG00000161813ENST00000551886F8W1Z5
ENSG00000161813ENST00000552445F8VZ60
ENSG00000161813ENST00000614335Q8TBL5
ENSG00000161813ENST00000615080A0A087WTL9

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381646262024LARP4 is an RNA-binding protein that binds nuclear-encoded mitochondrial mRNAs to promote mitochondrial function.1
386786102024Biological functions of Circular RNA_LARP4/ Upstream frameshift 1 in development of gastric cancer.0
381646262024LARP4 is an RNA-binding protein that binds nuclear-encoded mitochondrial mRNAs to promote mitochondrial function.1
386786102024Biological functions of Circular RNA_LARP4/ Upstream frameshift 1 in development of gastric cancer.0
367305442023CircBNC2 affects epithelial ovarian cancer progression through the miR-223-3p/ LARP4 axis.2
367305442023CircBNC2 affects epithelial ovarian cancer progression through the miR-223-3p/ LARP4 axis.2
316421102020Circular RNA LARP4 correlates with decreased Enneking stage, better histological response, and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging microRNA-424 in osteosarcoma.20
318978982020Circular RNA_LARP4 Sponges miR-1323 and Hampers Progression of Esophageal Squamous Cell Carcinoma Through Modulating PTEN/PI3K/AKT Pathway.20
321415552020Circular RNA_LARP4 inhibits the progression of non-small-cell lung cancer by regulating the expression of SMAD7.8
321877432020Circular RNA La-related RNA-binding protein 4 correlates with reduced tumor stage, as well as better prognosis, and promotes chemosensitivity to doxorubicin in breast cancer.15
324958632020Circular RNA_LARP4 inhibits cell migration and invasion of prostate cancer by targeting FOXO3A.7
327444992020Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails.14
316421102020Circular RNA LARP4 correlates with decreased Enneking stage, better histological response, and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging microRNA-424 in osteosarcoma.20
318978982020Circular RNA_LARP4 Sponges miR-1323 and Hampers Progression of Esophageal Squamous Cell Carcinoma Through Modulating PTEN/PI3K/AKT Pathway.20
321415552020Circular RNA_LARP4 inhibits the progression of non-small-cell lung cancer by regulating the expression of SMAD7.8

Citation

Dessen P

LARP4 (La ribonucleoprotein 4)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57369/larp4-(la-ribonucleoprotein-4)