ATP5IF1 (ATP synthase inhibitory factor subunit 1)

2018-02-01  

Identity

HGNC
ATP5IF1
LOCATION
1p35.3
LOCUSID
93974
ALIAS
ATPI,ATPIF1,ATPIP,IP

Other Information

Locus ID:

NCBI: 93974
MIM: 614981
HGNC: 871
Ensembl: ENSG00000130770

Variants:

dbSNP: 93974
ClinVar: 93974
TCGA: ENSG00000130770
COSMIC: ATP5IF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130770ENST00000335514Q9UII2
ENSG00000130770ENST00000465645Q9UII2
ENSG00000130770ENST00000468425A0A0B4J230
ENSG00000130770ENST00000497986Q9UII2

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
205386132010Up-regulation of the ATPase inhibitory factor 1 (IF1) of the mitochondrial H+-ATP synthase in human tumors mediates the metabolic shift of cancer cells to a Warburg phenotype.68
223423432012The mitochondrial ATPase inhibitory factor 1 triggers a ROS-mediated retrograde prosurvival and proliferative response.66
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
250428642014Reciprocal activation between ATPase inhibitory factor 1 and NF-κB drives hepatocellular carcinoma angiogenesis and metastasis.48
240053192013Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy.30
268764302016The ATPase Inhibitory Factor 1 (IF1): A master regulator of energy metabolism and of cell survival.28
231354032012Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts.27
233485672013IF1 limits the apoptotic-signalling cascade by preventing mitochondrial remodelling.24
245216702014In vivo inhibition of the mitochondrial H+-ATP synthase in neurons promotes metabolic preconditioning.24
246851402014Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.23

Citation

Dessen P

ATP5IF1 (ATP synthase inhibitory factor subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57371/atp5if1-(atp-synthase-inhibitory-factor-subunit-1)