UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked)

2018-07-01  

Identity

HGNC
UTY
LOCATION
Yq11.221
LOCUSID
7404
ALIAS
KDM6AL,KDM6C,UTY1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7404
MIM: 400009
HGNC: 12638
Ensembl: ENSG00000183878

Variants:

dbSNP: 7404
ClinVar: 7404
TCGA: ENSG00000183878
COSMIC: UTY

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183878ENST00000329134O14607
ENSG00000183878ENST00000331397O14607
ENSG00000183878ENST00000362096O14607
ENSG00000183878ENST00000382893A6NCS7
ENSG00000183878ENST00000382896O14607
ENSG00000183878ENST00000537580A0A096LPD8
ENSG00000183878ENST00000538878F5H3N7
ENSG00000183878ENST00000540140F5GWV3
ENSG00000183878ENST00000545955F5H8B4
ENSG00000183878ENST00000612274A0A087X2I9
ENSG00000183878ENST00000617789A0A087X0Y2
ENSG00000183878ENST00000618474A0A087X248
ENSG00000183878ENST00000624098O14607

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDMs demethylate histonesREACTOMER-HSA-3214842

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
355040052022Y-Chromosome Gene, Uty, Protects Against Pulmonary Hypertension by Reducing Proinflammatory Chemokines.17
355040052022Y-Chromosome Gene, Uty, Protects Against Pulmonary Hypertension by Reducing Proinflammatory Chemokines.17
319049962020Identification of Potential Biomarkers for Intervertebral Disc Degeneration Using the Genome-Wide Expression Analysis.1
327322232020X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.21
330406442020Increased Expression of Y-Encoded Demethylases During Differentiation of Human Male Neural Stem Cells.4
319049962020Identification of Potential Biomarkers for Intervertebral Disc Degeneration Using the Genome-Wide Expression Analysis.1
327322232020X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.21
330406442020Increased Expression of Y-Encoded Demethylases During Differentiation of Human Male Neural Stem Cells.4
310973642019Lysine demethylases KDM6A and UTY: The X and Y of histone demethylation.33
310973642019Lysine demethylases KDM6A and UTY: The X and Y of histone demethylation.33
275330812016Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer.14
275330812016Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer.14
247983372014Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase.102
247983372014Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase.102
185116972008Genetic variants of Y chromosome are associated with a protective lipid profile in black men.14

Citation

Dessen P

UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57388