Identity
HGNC
LOCATION
9q34.11
LOCUSID
ALIAS
CFAP133,DIC5,FAP133,SRTD11,WDR34,bA216B9.3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 89891
MIM: 613363
HGNC: 28296
Ensembl: ENSG00000119333
Variants:
dbSNP: 89891
ClinVar: 89891
TCGA: ENSG00000119333
COSMIC: DYNC2I2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000119333 | ENST00000372715 | Q96EX3 |
| ENSG00000119333 | ENST00000419989 | A2A3F8 |
| ENSG00000119333 | ENST00000451652 | A2A3F9 |
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Organelle biogenesis and maintenance | REACTOME | R-HSA-1852241 |
| Cilium Assembly | REACTOME | R-HSA-5617833 |
| Intraflagellar transport | REACTOME | R-HSA-5620924 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33124039 | 2021 | WDR34, a candidate gene for non-syndromic rod-cone dystrophy. | 4 |
| 33124039 | 2021 | WDR34, a candidate gene for non-syndromic rod-cone dystrophy. | 4 |
| 32576942 | 2020 | WDR34 mutation from anencephaly patients impaired both SHH and PCP signaling pathways. | 3 |
| 32576942 | 2020 | WDR34 mutation from anencephaly patients impaired both SHH and PCP signaling pathways. | 3 |
| 30649997 | 2019 | Interactions of the dynein-2 intermediate chain WDR34 with the light chains are required for ciliary retrograde protein trafficking. | 27 |
| 30877610 | 2019 | WDR34 Activates Wnt/Beta-Catenin Signaling in Hepatocellular Carcinoma. | 3 |
| 30649997 | 2019 | Interactions of the dynein-2 intermediate chain WDR34 with the light chains are required for ciliary retrograde protein trafficking. | 27 |
| 30877610 | 2019 | WDR34 Activates Wnt/Beta-Catenin Signaling in Hepatocellular Carcinoma. | 3 |
| 29278705 | 2018 | Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer. | 7 |
| 30320547 | 2018 | Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function. | 27 |
| 29278705 | 2018 | Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer. | 7 |
| 30320547 | 2018 | Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function. | 27 |
| 24183449 | 2013 | WDR34 mutations that cause short-rib polydactyly syndrome type III/severe asphyxiating thoracic dysplasia reveal a role for the NF-κB pathway in cilia. | 45 |
| 24183451 | 2013 | Mutations in the gene encoding IFT dynein complex component WDR34 cause Jeune asphyxiating thoracic dystrophy. | 58 |
| 24183449 | 2013 | WDR34 mutations that cause short-rib polydactyly syndrome type III/severe asphyxiating thoracic dysplasia reveal a role for the NF-κB pathway in cilia. | 45 |
Citation
Dessen P
DYNC2I2 (dynein 2 intermediate chain 2)
Atlas Genet Cytogenet Oncol Haematol. 2018-07-01
Online version: http://atlasgeneticsoncology.org/gene/57389/dync2i2-(dynein-2-intermediate-chain-2)
