GRIK2 (glutamate ionotropic receptor kainate type subunit 2)

2018-07-01  

Identity

HGNC
GRIK2
LOCATION
6q16.3
LOCUSID
2898
ALIAS
EAA4,GLR6,GLUK6,GLUR6,GluK2,MRT6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2898
MIM: 138244
HGNC: 4580
Ensembl: ENSG00000164418

Variants:

dbSNP: 2898
ClinVar: 2898
TCGA: ENSG00000164418
COSMIC: GRIK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164418ENST00000318991A0A0A0MR30
ENSG00000164418ENST00000358361G3XAD3
ENSG00000164418ENST00000369134F8WEZ8
ENSG00000164418ENST00000369137A0A0A0MRL4
ENSG00000164418ENST00000369138Q13002
ENSG00000164418ENST00000413795Q13002
ENSG00000164418ENST00000421544Q13002
ENSG00000164418ENST00000436862H7C2P5
ENSG00000164418ENST00000455610H7BZX7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Activation of Kainate Receptors upon glutamate bindingREACTOMER-HSA-451326
Ionotropic activity of Kainate ReceptorsREACTOMER-HSA-451306
Activation of Na-permeable Kainate ReceptorsREACTOMER-HSA-451307
Activation of Ca-permeable Kainate ReceptorREACTOMER-HSA-451308

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379908862023Epigenetic signature discriminates lymphatic metastasis in BRAF wild-type thyroid carcinoma: methylation role of GRIK2.0
379908862023Epigenetic signature discriminates lymphatic metastasis in BRAF wild-type thyroid carcinoma: methylation role of GRIK2.0
347301792022The Deletion of GluK2 Alters Cholinergic Control of Neuronal Excitability.1
347301792022The Deletion of GluK2 Alters Cholinergic Control of Neuronal Excitability.1
343755872021Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders.12
345522412021Kainate receptor modulation by NETO2.9
343755872021Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders.12
345522412021Kainate receptor modulation by NETO2.9
305874992019Isoforms of Ionotropic Glutamate Receptor GRIK2 Induce Senescence of Carcinoma Cells.3
309085862019Interaction among GRIK2 gene on epilepsy susceptibility in Chinese children.1
316315872019Correlation between GRIK2 rs6922753, rs2227283 polymorphism and aggressive behaviors with Bipolar Mania in the Chinese Han population.3
305874992019Isoforms of Ionotropic Glutamate Receptor GRIK2 Induce Senescence of Carcinoma Cells.3
309085862019Interaction among GRIK2 gene on epilepsy susceptibility in Chinese children.1
316315872019Correlation between GRIK2 rs6922753, rs2227283 polymorphism and aggressive behaviors with Bipolar Mania in the Chinese Han population.3
295272402018Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD.17

Citation

Dessen P

GRIK2 (glutamate ionotropic receptor kainate type subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57393/grik2-(glutamate-ionotropic-receptor-kainate-type-subunit-2)