Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7915
MIM: 610045
HGNC: 408
Ensembl: ENSG00000112294
Variants:
dbSNP: 7915
ClinVar: 7915
TCGA: ENSG00000112294
COSMIC: ALDH5A1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA445043 | Opioid-Related Disorders | Disease | ClinicalAnnotation | associated | PD | 24230997 | |
| PA450401 | methadone | Chemical | ClinicalAnnotation | associated | PD | 24230997 | |
| PA451846 | valproic acid | Chemical | Pathway | associated | 23407051 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38110041 | 2024 | ALDH5A1-deficient iPSC-derived excitatory and inhibitory neurons display cell type specific alterations. | 2 |
| 38658850 | 2024 | Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder. | 1 |
| 38791277 | 2024 | Functional Characterization of a Spectrum of Genetic Variants in a Family with Succinic Semialdehyde Dehydrogenase Deficiency. | 0 |
| 38110041 | 2024 | ALDH5A1-deficient iPSC-derived excitatory and inhibitory neurons display cell type specific alterations. | 2 |
| 38658850 | 2024 | Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder. | 1 |
| 38791277 | 2024 | Functional Characterization of a Spectrum of Genetic Variants in a Family with Succinic Semialdehyde Dehydrogenase Deficiency. | 0 |
| 36976494 | 2023 | Glioma Cells Expressing High Levels of ALDH5A1 Exhibit Enhanced Migration Transcriptional Signature in Patient Tumors. | 2 |
| 37962671 | 2023 | Phenotypic correlates of structural and functional protein impairments resultant from ALDH5A1 variants. | 5 |
| 36976494 | 2023 | Glioma Cells Expressing High Levels of ALDH5A1 Exhibit Enhanced Migration Transcriptional Signature in Patient Tumors. | 2 |
| 37962671 | 2023 | Phenotypic correlates of structural and functional protein impairments resultant from ALDH5A1 variants. | 5 |
| 32881051 | 2021 | ALDH5A1 acts as a tumour promoter and has a prognostic impact in papillary thyroid carcinoma. | 9 |
| 33319393 | 2021 | Gene expression analysis in epileptic hippocampi reveals a promoter haplotype conferring reduced aldehyde dehydrogenase 5a1 expression and responsiveness. | 1 |
| 34882073 | 2021 | Assessing Prevalence and Carrier Frequency of Succinic Semialdehyde Dehydrogenase Deficiency. | 7 |
| 32881051 | 2021 | ALDH5A1 acts as a tumour promoter and has a prognostic impact in papillary thyroid carcinoma. | 9 |
| 33319393 | 2021 | Gene expression analysis in epileptic hippocampi reveals a promoter haplotype conferring reduced aldehyde dehydrogenase 5a1 expression and responsiveness. | 1 |
Citation
Dessen P
ALDH5A1 (aldehyde dehydrogenase 5 family member A1)
Atlas Genet Cytogenet Oncol Haematol. 2018-07-01
Online version: http://atlasgeneticsoncology.org/gene/57398/aldh5a1-(aldehyde-dehydrogenase-5-family-member-a1)
