EMC6 (ER membrane protein complex subunit 6)

2018-07-01  

Identity

HGNC
EMC6
LOCATION
17p13.2
LOCUSID
83460
ALIAS
RAB5IFL,TMEM93
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83460
HGNC: 28430
Ensembl: ENSG00000127774

Variants:

dbSNP: 83460
ClinVar: 83460
TCGA: ENSG00000127774
COSMIC: EMC6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127774ENST00000248378Q9BV81
ENSG00000127774ENST00000397133Q9BV81

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384458072024Inhibition of UBA52 induces autophagy via EMC6 to suppress hepatocellular carcinoma tumorigenesis and progression.1
384458072024Inhibition of UBA52 induces autophagy via EMC6 to suppress hepatocellular carcinoma tumorigenesis and progression.1
331775052020EMC6 regulates acinar apoptosis via APAF1 in acute and chronic pancreatitis.14
331775052020EMC6 regulates acinar apoptosis via APAF1 in acute and chronic pancreatitis.14
309825752019Ad5-EMC6 mediates antitumor activity in gastric cancer cells through the mitochondrial apoptosis pathway.7
309825752019Ad5-EMC6 mediates antitumor activity in gastric cancer cells through the mitochondrial apoptosis pathway.7
286481452017ER membrane protein complex subunit 6 (EMC6) is a novel tumor suppressor in gastric cancer.13
287422032017Expression levels and roles of EMC-6, Beclin1, and Rab5a in the cervical cancer.8
286481452017ER membrane protein complex subunit 6 (EMC6) is a novel tumor suppressor in gastric cancer.13
287422032017Expression levels and roles of EMC-6, Beclin1, and Rab5a in the cervical cancer.8
231829412013A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy.38
231829412013A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy.38

Citation

Dessen P

EMC6 (ER membrane protein complex subunit 6)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57402/emc6-(er-membrane-protein-complex-subunit-6)