Identity
HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
CLAX,LLT1,OCIL
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 29121
MIM: 605659
HGNC: 14351
Ensembl: ENSG00000069493
Variants:
dbSNP: 29121
ClinVar: 29121
TCGA: ENSG00000069493
COSMIC: CLEC2D
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Adaptive Immune System | REACTOME | R-HSA-1280218 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | REACTOME | R-HSA-198933 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38502058 | 2024 | Immune checkpoint CD161/LLT1-associated immunological landscape and diagnostic value in oral squamous cell carcinoma. | 1 |
| 38673902 | 2024 | Lectin-like Transcript-1 (LLT1) Expression in Oral Squamous Cell Carcinomas: Prognostic Significance and Relationship with the Tumor Immune Microenvironment. | 0 |
| 38502058 | 2024 | Immune checkpoint CD161/LLT1-associated immunological landscape and diagnostic value in oral squamous cell carcinoma. | 1 |
| 38673902 | 2024 | Lectin-like Transcript-1 (LLT1) Expression in Oral Squamous Cell Carcinomas: Prognostic Significance and Relationship with the Tumor Immune Microenvironment. | 0 |
| 37287972 | 2023 | SARS-CoV-2 infection impairs NK cell functions via activation of the LLT1-CD161 axis. | 9 |
| 37287972 | 2023 | SARS-CoV-2 infection impairs NK cell functions via activation of the LLT1-CD161 axis. | 9 |
| 35185935 | 2022 | LLT1-CD161 Interaction in Cancer: Promises and Challenges. | 18 |
| 35185935 | 2022 | LLT1-CD161 Interaction in Cancer: Promises and Challenges. | 18 |
| 31859049 | 2020 | Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury. | 33 |
| 32449811 | 2020 | Docetaxel suppresses immunotherapy efficacy of natural killer cells toward castration-resistant prostate cancer cells via altering androgen receptor-lectin-like transcript 1 signals. | 5 |
| 33288556 | 2020 | Role of LLT1 and PCNA as Natural Killer Cell Immune Evasion Strategies of HCT 116 Cells. | 8 |
| 31859049 | 2020 | Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury. | 33 |
| 32449811 | 2020 | Docetaxel suppresses immunotherapy efficacy of natural killer cells toward castration-resistant prostate cancer cells via altering androgen receptor-lectin-like transcript 1 signals. | 5 |
| 33288556 | 2020 | Role of LLT1 and PCNA as Natural Killer Cell Immune Evasion Strategies of HCT 116 Cells. | 8 |
| 30955082 | 2019 | Lectin-like transcript 1 (LLT1) expression is associated with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma. | 7 |
Citation
Dessen P
CLEC2D (C-type lectin domain family 2 member D)
Atlas Genet Cytogenet Oncol Haematol. 2018-07-01
Online version: http://atlasgeneticsoncology.org/gene/57404/clec2d-(c-type-lectin-domain-family-2-member-d)
