CLEC2D (C-type lectin domain family 2 member D)

2018-07-01 Affiliation

Identity

HGNC

CLEC2D

LOCATION

12p13.31

LOCUSID

29121

ALIAS

CLAX,LLT1,OCIL

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 29121
MIM: 605659
HGNC: 14351
Ensembl: ENSG00000069493

Variants:

dbSNP: 29121
ClinVar: 29121
TCGA: ENSG00000069493
COSMIC: CLEC2D

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000069493	ENST00000261339	Q9UHP7
ENSG00000069493	ENST00000261339	W8JXM2
ENSG00000069493	ENST00000261340	Q9UHP7
ENSG00000069493	ENST00000290855	Q9UHP7
ENSG00000069493	ENST00000325960	F8WF99
ENSG00000069493	ENST00000430909	A0A0C4DG81
ENSG00000069493	ENST00000444971	F8WF99
ENSG00000069493	ENST00000460309	H0YGG6
ENSG00000069493	ENST00000466035	H0YH49
ENSG00000069493	ENST00000476198	F5H0P0
ENSG00000069493	ENST00000479877	Q9UHP7
ENSG00000069493	ENST00000492359	F5H5U4
ENSG00000069493	ENST00000536355	F5H0P0
ENSG00000069493	ENST00000543300	Q9UHP7
ENSG00000069493	ENST00000544322	A0A0C4DGG4
ENSG00000069493	ENST00000545918	Q9UHP7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	REACTOME	R-HSA-198933

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
16339512	2005	Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor.	83
16339513	2005	Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor.	83
18453569	2008	Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells.	58
21930700	2011	Induction of lectin-like transcript 1 (LLT1) protein cell surface expression by pathogens and interferon-γ contributes to modulate immune responses.	48
18593762	2008	Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency.	37
20843815	2010	Characterization of alternatively spliced transcript variants of CLEC2D gene.	21
21572041	2011	Molecular basis for LLT1 protein recognition by human CD161 protein (NKRP1A/KLRB1).	16
15104121	2004	The LLT1 receptor induces IFN-gamma production by human natural killer cells.	12
26829983	2016	LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation.	12
27626681	2016	Overexpression of LLT1 (OCIL, CLEC2D) on prostate cancer cells inhibits NK cell-mediated killing through LLT1-NKRP1A (CD161) interaction.	7

Citation

Dessen P

CLEC2D (C-type lectin domain family 2 member D)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57404/clec2d-(c-type-lectin-domain-family-2-member-d)