TAAR1 (trace amine associated receptor 1)

2018-07-01  

Identity

HGNC
LOCATION
6q23.2
LOCUSID
ALIAS
TA1,TAR1,TRAR1

Other Information

Locus ID:

NCBI: 134864
MIM: 609333
HGNC: 17734
Ensembl: ENSG00000146399

Variants:

dbSNP: 134864
ClinVar: 134864
TCGA: ENSG00000146399
COSMIC: TAAR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146399ENST00000275216Q96RJ0

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381681182024Molecular basis of human trace amine-associated receptor 1 activation.3
381681182024Molecular basis of human trace amine-associated receptor 1 activation.3
370282792023Thymosin α1 interacts with Galectin-1 modulating the β-galactosides affinity and inducing alteration in the biological activity.1
375113282023T1AM/TAAR1 System Reduces Inflammatory Response and β-Amyloid Toxicity in Human Microglial HMC3 Cell Line.6
379353762023Ligand recognition and G-protein coupling of trace amine receptor TAAR1.7
379634652023Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.6
370282792023Thymosin α1 interacts with Galectin-1 modulating the β-galactosides affinity and inducing alteration in the biological activity.1
375113282023T1AM/TAAR1 System Reduces Inflammatory Response and β-Amyloid Toxicity in Human Microglial HMC3 Cell Line.6
379353762023Ligand recognition and G-protein coupling of trace amine receptor TAAR1.7
379634652023Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.6
328162352021Cadaverine and Spermine Elicit Ca(2+) Uptake in Human CP Cells via a Trace Amine-Associated Receptor 1 Dependent Pathway.2
344451812021Trace Amine-Associated Receptor 1 (TAAR1) Is a Positive Prognosticator for Epithelial Ovarian Cancer.6
345372652021Trace amine-associated receptor 1 (TAAR1): Potential application in mood disorders: A systematic review.8
347690072021TAAR1 Expression in Human Macrophages and Brain Tissue: A Potential Novel Facet of MS Neuroinflammation.12
350086362021Search for Structural Basis of Interactions of Biogenic Amines with Human TAAR1 and TAAR6 Receptors.6

Citation

Dessen P

TAAR1 (trace amine associated receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57405/taar1-(trace-amine-associated-receptor-1)