TAS2R16 (taste 2 receptor member 16)

2018-07-01  

Identity

HGNC
LOCATION
7q31.32
LOCUSID
ALIAS
BGLPT,T2R16

Other Information

Locus ID:

NCBI: 50833
MIM: 604867
HGNC: 14921
Ensembl: ENSG00000128519

Variants:

dbSNP: 50833
ClinVar: 50833
TCGA: ENSG00000128519
COSMIC: TAS2R16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128519ENST00000249284Q9NYV7

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Taste transductionKEGGko04742
Taste transductionKEGGhsa04742
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443309AlcoholismDiseaseClinicalAnnotationassociatedPD
PA448073ethanolChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
381111402024Association of TAS2R16 gene (rs860170, rs978739, rs1357949) polymorphisms and TAS2R16 serum levels in patients with age-related macular degeneration.1
381111402024Association of TAS2R16 gene (rs860170, rs978739, rs1357949) polymorphisms and TAS2R16 serum levels in patients with age-related macular degeneration.1
349758342021TAS2R16 Activation Suppresses LPS-Induced Cytokine Expression in Human Gingival Fibroblasts.17
349758342021TAS2R16 Activation Suppresses LPS-Induced Cytokine Expression in Human Gingival Fibroblasts.17
329879262020Suppression of hTAS2R16 Signaling by Umami Substances.5
329879262020Suppression of hTAS2R16 Signaling by Umami Substances.5
311864542019Dual binding mode of "bitter sugars" to their human bitter taste receptor target.17
311864542019Dual binding mode of "bitter sugars" to their human bitter taste receptor target.17
283667702017A bio-cultural approach to the study of food choice: The contribution of taste genetics, population and culture.16
289158992017Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer.16
283667702017A bio-cultural approach to the study of food choice: The contribution of taste genetics, population and culture.16
289158992017Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer.16
253939782015Principal component analysis of binding energies for single-point mutants of hT2R16 bound to an agonist correlate with experimental mutant cell response.8
253939782015Principal component analysis of binding energies for single-point mutants of hT2R16 bound to an agonist correlate with experimental mutant cell response.8
241771852014Origin and differential selection of allelic variation at TAS2R16 associated with salicin bitter taste sensitivity in Africa.23

Citation

Dessen P

TAS2R16 (taste 2 receptor member 16)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57422/tas2r16-(taste-2-receptor-member-16)