OGA (O-GlcNAcase)

2018-07-01  

Identity

HGNC
OGA
LOCATION
10q24.32
LOCUSID
10724
ALIAS
MEA5,MGEA5,NCOAT

Other Information

Locus ID:

NCBI: 10724
MIM: 604039
HGNC: 7056
Ensembl: ENSG00000198408

Variants:

dbSNP: 10724
ClinVar: 10724
TCGA: ENSG00000198408
COSMIC: OGA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198408ENST00000357797O60502
ENSG00000198408ENST00000361464O60502
ENSG00000198408ENST00000370094O60502
ENSG00000198408ENST00000429860H7C3X0
ENSG00000198408ENST00000439817O60502

Pathways

PathwaySourceExternal ID
Insulin resistanceKEGGhsa04931

References

Pubmed IDYearTitleCitations
379074622023Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex.3
379074622023Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex.3
361249992022Inhibition of O-GlcNAcase Inhibits Hematopoietic and Leukemic Stem Cell Self-Renewal and Drives Dendritic Cell Differentiation via STAT3/5 Signaling.11
361249992022Inhibition of O-GlcNAcase Inhibits Hematopoietic and Leukemic Stem Cell Self-Renewal and Drives Dendritic Cell Differentiation via STAT3/5 Signaling.11
323654082021Pharmacological inhibition and knockdown of O-GlcNAcase reduces cellular internalization of α-synuclein preformed fibrils.17
333107512021Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice.15
333330922021Elucidating the protein substrate recognition of O-GlcNAc transferase (OGT) toward O-GlcNAcase (OGA) using a GlcNAc electrophilic probe.9
341353142021OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair.6
323654082021Pharmacological inhibition and knockdown of O-GlcNAcase reduces cellular internalization of α-synuclein preformed fibrils.17
333107512021Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice.15
333330922021Elucidating the protein substrate recognition of O-GlcNAc transferase (OGT) toward O-GlcNAcase (OGA) using a GlcNAc electrophilic probe.9
341353142021OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair.6
315015202020O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth.25
330867282020Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity.8
315015202020O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth.25

Citation

Dessen P

OGA (O-GlcNAcase)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57432