MS4A2 (membrane spanning 4-domains A2)

2018-07-01  

Identity

HGNC
LOCATION
11q12.1
LOCUSID
ALIAS
APY,ATOPY,FCER1B,FCERI,IGEL,IGER,IGHER,MS4A1

Other Information

Locus ID:

NCBI: 2206
MIM: 147138
HGNC: 7316
Ensembl: ENSG00000149534

Variants:

dbSNP: 2206
ClinVar: 2206
TCGA: ENSG00000149534
COSMIC: MS4A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149534ENST00000278888Q01362
ENSG00000149534ENST00000524868E9PLJ1
ENSG00000149534ENST00000617306A0A0B4J2E9

Expression (GTEx)

0
1
2
3
4
5
6

Pathways

PathwaySourceExternal ID
Fc epsilon RI signaling pathwayKEGGko04664
AsthmaKEGGko05310
Fc epsilon RI signaling pathwayKEGGhsa04664
AsthmaKEGGhsa05310
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
364248952023Identification of redundancy between human FcεRIβ and MS4A6A proteins points toward additional complex mechanisms for FcεRI trafficking and signaling.4
381586882023Evaluation value and mechanism of ADRB2 and FCER1B gene polymorphisms in preterm infants with congenital respiratory diseases.0
364248952023Identification of redundancy between human FcεRIβ and MS4A6A proteins points toward additional complex mechanisms for FcεRI trafficking and signaling.4
381586882023Evaluation value and mechanism of ADRB2 and FCER1B gene polymorphisms in preterm infants with congenital respiratory diseases.0
342614692021Interaction between antibiotic use and MS4A2 gene polymorphism on childhood eczema: a prospective birth cohort study.1
342614692021Interaction between antibiotic use and MS4A2 gene polymorphism on childhood eczema: a prospective birth cohort study.1
287752092017Role for High-Affinity IgE Receptor in Prognosis of Lung Adenocarcinoma Patients.12
287752092017Role for High-Affinity IgE Receptor in Prognosis of Lung Adenocarcinoma Patients.12
267923852016A Nonsynonymous FCER1B SNP is Associated with Risk of Developing Allergic Rhinitis and with IgE Levels.8
271573942016Genome-wide expression profiling in the peripheral blood of patients with fibromyalgia.23
267923852016A Nonsynonymous FCER1B SNP is Associated with Risk of Developing Allergic Rhinitis and with IgE Levels.8
271573942016Genome-wide expression profiling in the peripheral blood of patients with fibromyalgia.23
249532552015IgE FcɛR1β polymorphism and risk of developing chronic spontaneous urticaria: A study in an ethnic Kashmiri population.1
255301332015Association between FcεRIβ and IFN-γ Polymorphisms and Asthma in Asian Population: a Meta-Analysis.2
256583512015Nanodomains in early and later phases of FcɛRI signalling.11

Citation

Dessen P

MS4A2 (membrane spanning 4-domains A2)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57438/ms4a2-(membrane-spanning-4-domains-a2)