MSTO1 (misato mitochondrial distribution and morphology regulator 1)

2018-07-01  

Identity

HGNC
LOCATION
1q22
LOCUSID
ALIAS
LST005,MMYAT,MST

Other Information

Locus ID:

NCBI: 55154
MIM: 617619
HGNC: 29678
Ensembl: ENSG00000125459

Variants:

dbSNP: 55154
ClinVar: 55154
TCGA: ENSG00000125459
COSMIC: MSTO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125459ENST00000245564Q9BUK6
ENSG00000125459ENST00000368341Q9BUK6
ENSG00000125459ENST00000462250V9GYF2
ENSG00000125459ENST00000490743Q9BUK6
ENSG00000125459ENST00000649846A0A3B3IUD2

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
374318162023Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy.3
374318162023Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy.3
332220312021Evidence of motor axon or motor neuron damage in a Chinese patient with compound heterozygous MSTO1 variants.3
332220312021Evidence of motor axon or motor neuron damage in a Chinese patient with compound heterozygous MSTO1 variants.3
306846682020Whole-exome sequencing identifies rare compound heterozygous mutations in the MSTO1 gene associated with cerebellar ataxia and myopathy.6
306846682020Whole-exome sequencing identifies rare compound heterozygous mutations in the MSTO1 gene associated with cerebellar ataxia and myopathy.6
314635722019MSTO1 mutations cause mtDNA depletion, manifesting as muscular dystrophy with cerebellar involvement.15
314635722019MSTO1 mutations cause mtDNA depletion, manifesting as muscular dystrophy with cerebellar involvement.15
293397792018Novel recessive mutations in MSTO1 cause cerebellar atrophy with pigmentary retinopathy.8
293397792018Novel recessive mutations in MSTO1 cause cerebellar atrophy with pigmentary retinopathy.8
285442752017Recessive mutations in MSTO1 cause mitochondrial dynamics impairment, leading to myopathy and ataxia.25
285549422017MSTO1 is a cytoplasmic pro-mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans.34
285442752017Recessive mutations in MSTO1 cause mitochondrial dynamics impairment, leading to myopathy and ataxia.25
285549422017MSTO1 is a cytoplasmic pro-mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans.34
173499982007Human Misato regulates mitochondrial distribution and morphology.19

Citation

Dessen P

MSTO1 (misato mitochondrial distribution and morphology regulator 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57443/msto1-(misato-mitochondrial-distribution-and-morphology-regulator-1)