CLEC6A (C-type lectin domain containing 6A)

2018-07-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
CLEC4N,CLECSF10,dectin-2,hDECTIN-2

Other Information

Locus ID:

NCBI: 93978
MIM: 613579
HGNC: 14556
Ensembl: ENSG00000205846

Variants:

dbSNP: 93978
ClinVar: 93978
TCGA: ENSG00000205846
COSMIC: CLEC6A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000205846ENST00000382073Q6EIG7

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
Dectin-2 familyREACTOMER-HSA-5621480

References

Pubmed IDYearTitleCitations
212837872011Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2.64
236066322013The Dectin-2 family of C-type lectin-like receptors: an update.64
256591412015Recognition of Aspergillus fumigatus hyphae by human plasmacytoid dendritic cells is mediated by dectin-2 and results in formation of extracellular traps.44
241291602014Dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation.20
158108862005Identification and expression profiling of a human C-type lectin, structurally homologous to mouse dectin-2.17
296687082018Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses.16
278722902016The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.13
286524052017Mechanism of pathogen recognition by human dectin-2.13
261298892015Dectin-2 polymorphism associated with pulmonary cryptococcosis in HIV-uninfected Chinese patients.12
273584012016Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells.9

Citation

Dessen P

CLEC6A (C-type lectin domain containing 6A)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57471/clec6a-(c-type-lectin-domain-containing-6a)