USP48 (ubiquitin specific peptidase 48)

2018-07-01  

Identity

HGNC
LOCATION
1p36.12
LOCUSID
ALIAS
RAP1GA1,USP31
FUSION GENES

Other Information

Locus ID:

NCBI: 84196
MIM: 617445
HGNC: 18533
Ensembl: ENSG00000090686

Variants:

dbSNP: 84196
ClinVar: 84196
TCGA: ENSG00000090686
COSMIC: USP48

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090686ENST00000308271Q86UV5
ENSG00000090686ENST00000374730H3BLX5
ENSG00000090686ENST00000374732A0A0A0MRS6
ENSG00000090686ENST00000400301Q86UV5
ENSG00000090686ENST00000421625Q86UV5
ENSG00000090686ENST00000526044E9PJH5
ENSG00000090686ENST00000527823E9PRY5
ENSG00000090686ENST00000529637Q86UV5
ENSG00000090686ENST00000532737E9PJ87
ENSG00000090686ENST00000534705E9PJ93

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
375535032023CircUSP48 promotes malignant behavior by regulating CYR61 via miR-365 in osteosarcoma.0
375535032023CircUSP48 promotes malignant behavior by regulating CYR61 via miR-365 in osteosarcoma.0
346642152022USP8, USP48, and BRAF mutations differ in their genotype-phenotype correlation in Asian Indian patients with Cushing's disease.7
354138382022miR-489-3p promotes malignant progression of non-small cell lung cancer through the inactivation of Wnt/β-catenin signaling pathway via regulating USP48.7
359136422022USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection.4
346642152022USP8, USP48, and BRAF mutations differ in their genotype-phenotype correlation in Asian Indian patients with Cushing's disease.7
354138382022miR-489-3p promotes malignant progression of non-small cell lung cancer through the inactivation of Wnt/β-catenin signaling pathway via regulating USP48.7
359136422022USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection.4
339031202021USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular Carcinoma via Regulating SIRT6 Stabilization.53
344452142021USP48 Governs Cell Cycle Progression by Regulating the Protein Level of Aurora B.6
339031202021USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular Carcinoma via Regulating SIRT6 Stabilization.53
344452142021USP48 Governs Cell Cycle Progression by Regulating the Protein Level of Aurora B.6
321592472020LINC00467 enhances head and neck squamous cell carcinoma progression and the epithelial-mesenchymal transition process via miR-299-5p/ubiquitin specific protease-48 axis.14
323593362020USP48 Sustains Chemoresistance and Metastasis in Ovarian Cancer.4
321592472020LINC00467 enhances head and neck squamous cell carcinoma progression and the epithelial-mesenchymal transition process via miR-299-5p/ubiquitin specific protease-48 axis.14

Citation

Dessen P

USP48 (ubiquitin specific peptidase 48)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57481/usp48-(ubiquitin-specific-peptidase-48)