RNF183 (ring finger protein 183)

2018-07-01  

Identity

HGNC
LOCATION
9q32
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 138065
HGNC: 28721
Ensembl: ENSG00000165188

Variants:

dbSNP: 138065
ClinVar: 138065
TCGA: ENSG00000165188
COSMIC: RNF183

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165188ENST00000297894Q96D59
ENSG00000165188ENST00000297894A0A024R834
ENSG00000165188ENST00000416588Q96D59
ENSG00000165188ENST00000416588A0A024R834
ENSG00000165188ENST00000441031Q96D59
ENSG00000165188ENST00000441031A0A024R834
ENSG00000165188ENST00000478815Q96D59
ENSG00000165188ENST00000478815A0A024R834

Expression (GTEx)

0
1
2
3
4
5
6
7

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
372585722023The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression.2
372585722023The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression.2
351217372022Cathepsin D as a potential therapeutic target to enhance anticancer drug-induced apoptosis via RNF183-mediated destabilization of Bcl-xL in cancer cells.9
351217372022Cathepsin D as a potential therapeutic target to enhance anticancer drug-induced apoptosis via RNF183-mediated destabilization of Bcl-xL in cancer cells.9
317321532020Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.5
324862212020The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function.20
317321532020Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.5
324862212020The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function.20
293007662018Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183.6
295072302018Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL.26
293007662018Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183.6
295072302018Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL.26
287567702017Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells.8
287962652017RNF183 promotes proliferation and metastasis of colorectal cancer cells via activation of NF-κB-IL-8 axis.36
287567702017Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells.8

Citation

Dessen P

RNF183 (ring finger protein 183)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57492/rnf183-(ring-finger-protein-183)