Identity
HGNC
LOCATION
11q14.2
LOCUSID
ALIAS
C11orf73,HLD13,HSPC138,HSPC179,L7RN6,OPI10
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51501
MIM: 614908
HGNC: 26938
Ensembl: ENSG00000149196
Variants:
dbSNP: 51501
ClinVar: 51501
TCGA: ENSG00000149196
COSMIC: HIKESHI
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000149196 | ENST00000278483 | Q53FT3 |
| ENSG00000149196 | ENST00000528004 | E9PJB2 |
| ENSG00000149196 | ENST00000533986 | E9PPG8 |
| ENSG00000149196 | ENST00000618164 | A0A087WYW7 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Cellular responses to stress | REACTOME | R-HSA-2262752 |
| Cellular response to heat stress | REACTOME | R-HSA-3371556 |
| Regulation of HSF1-mediated heat shock response | REACTOME | R-HSA-3371453 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34111619 | 2021 | Further Delineation of the Clinical and Pathologic Features of HIKESHI-Related Hypomyelinating Leukodystrophy. | 0 |
| 34111619 | 2021 | Further Delineation of the Clinical and Pathologic Features of HIKESHI-Related Hypomyelinating Leukodystrophy. | 0 |
| 32377716 | 2020 | HIKESHI silencing can enhance mild hyperthermia sensitivity in human oral squamous cell carcinoma HSC‑3 cells. | 5 |
| 32377716 | 2020 | HIKESHI silencing can enhance mild hyperthermia sensitivity in human oral squamous cell carcinoma HSC‑3 cells. | 5 |
| 28000699 | 2017 | Absence of Hikeshi, a nuclear transporter for heat-shock protein HSP70, causes infantile hypomyelinating leukoencephalopathy. | 5 |
| 28731175 | 2017 | Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70. | 4 |
| 28980748 | 2017 | Hikeshi modulates the proteotoxic stress response in human cells: Implication for the importance of the nuclear function of HSP70s. | 3 |
| 28000699 | 2017 | Absence of Hikeshi, a nuclear transporter for heat-shock protein HSP70, causes infantile hypomyelinating leukoencephalopathy. | 5 |
| 28731175 | 2017 | Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70. | 4 |
| 28980748 | 2017 | Hikeshi modulates the proteotoxic stress response in human cells: Implication for the importance of the nuclear function of HSP70s. | 3 |
| 26545878 | 2016 | Leukoencephalopathy and early death associated with an Ashkenazi-Jewish founder mutation in the Hikeshi gene. | 12 |
| 26545878 | 2016 | Leukoencephalopathy and early death associated with an Ashkenazi-Jewish founder mutation in the Hikeshi gene. | 12 |
| 25760597 | 2015 | Structural and functional analysis of Hikeshi, a new nuclear transport receptor of Hsp70s. | 3 |
| 25760597 | 2015 | Structural and functional analysis of Hikeshi, a new nuclear transport receptor of Hsp70s. | 3 |
| 22541429 | 2012 | Hikeshi, a nuclear import carrier for Hsp70s, protects cells from heat shock-induced nuclear damage. | 58 |
Citation
Dessen P
HIKESHI (heat shock protein nuclear import factor hikeshi)
Atlas Genet Cytogenet Oncol Haematol. 2018-07-01
Online version: http://atlasgeneticsoncology.org/gene/57496/hikeshi-(heat-shock-protein-nuclear-import-factor-hikeshi)
