MYSM1 (Myb like, SWIRM and MPN domains 1)

2018-07-01  

Identity

HGNC
LOCATION
1p32.1
LOCUSID
ALIAS
2A-DUB,2ADUB,BMFS4
FUSION GENES

Other Information

Locus ID:

NCBI: 114803
MIM: 612176
HGNC: 29401
Ensembl: ENSG00000162601

Variants:

dbSNP: 114803
ClinVar: 114803
TCGA: ENSG00000162601
COSMIC: MYSM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162601ENST00000472487Q5VVJ2
ENSG00000162601ENST00000622766Q5VVJ2
ENSG00000162601ENST00000655340A0A590UJD8
ENSG00000162601ENST00000659108A0A590UJT8
ENSG00000162601ENST00000659812A0A590UK32
ENSG00000162601ENST00000665648A0A590UJW2

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Metalloprotease DUBsREACTOMER-HSA-5689901

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380652332024MYSM1 attenuates DNA damage signals triggered by physiologic and genotoxic DNA breaks.1
380652332024MYSM1 attenuates DNA damage signals triggered by physiologic and genotoxic DNA breaks.1
366110642023Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development.0
366110642023Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development.0
347067612021MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling.5
347067612021MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling.5
324665902020Interaction of Deubiquitinase 2A-DUB/MYSM1 with DNA Repair and Replication Factors.4
330860592020MYSM1 Represses Innate Immunity and Autoimmunity through Suppressing the cGAS-STING Pathway.31
324665902020Interaction of Deubiquitinase 2A-DUB/MYSM1 with DNA Repair and Replication Factors.4
330860592020MYSM1 Represses Innate Immunity and Autoimmunity through Suppressing the cGAS-STING Pathway.31
316073242019[Deubiquitinase MYSM1 Regulates Differentiation of Human B Cells to Plasma Cells].0
317617862019MYSM1-AR complex-mediated repression of Akt/c-Raf/GSK-3β signaling impedes castration-resistant prostate cancer growth.6
316073242019[Deubiquitinase MYSM1 Regulates Differentiation of Human B Cells to Plasma Cells].0
317617862019MYSM1-AR complex-mediated repression of Akt/c-Raf/GSK-3β signaling impedes castration-resistant prostate cancer growth.6
281152162017Myb-like, SWIRM, and MPN domains 1 (MYSM1) deficiency: Genotoxic stress-associated bone marrow failure and developmental aberrations.20

Citation

Dessen P

MYSM1 (Myb like, SWIRM and MPN domains 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57504/mysm1-(myb-like-swirm-and-mpn-domains-1)