SUCLG2 (succinate-CoA ligase GDP-forming subunit beta)

2018-07-01  

Identity

HGNC
SUCLG2
LOCATION
3p14.1
LOCUSID
8801
ALIAS
G-SCS,GBETA,GTPSCS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8801
MIM: 603922
HGNC: 11450
Ensembl: ENSG00000172340

Variants:

dbSNP: 8801
ClinVar: 8801
TCGA: ENSG00000172340
COSMIC: SUCLG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172340ENST00000307227Q96I99
ENSG00000172340ENST00000307227A0A024R325
ENSG00000172340ENST00000460567H0Y852
ENSG00000172340ENST00000492795E9PDQ8
ENSG00000172340ENST00000493112Q96I99

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Citrate cycle (TCA cycle)KEGGko00020
Propanoate metabolismKEGGko00640
Citrate cycle (TCA cycle)KEGGhsa00020
Propanoate metabolismKEGGhsa00640
Metabolic pathwaysKEGGhsa01100
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetateKEGGhsa_M00011
Citrate cycle (TCA cycle, Krebs cycle)KEGGM00009
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetateKEGGM00011
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
Citrate cycle (TCA cycle, Krebs cycle)KEGGhsa_M00009
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Citric acid cycle (TCA cycle)REACTOMER-HSA-71403

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
329633512020EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer.21
332646022020Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells.34
329633512020EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer.21
332646022020Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells.34
287099332017Identification of novel biomarker and therapeutic target candidates for diagnosis and treatment of follicular carcinoma.13
287099332017Identification of novel biomarker and therapeutic target candidates for diagnosis and treatment of follicular carcinoma.13
253704872015Localization of SUCLA2 and SUCLG2 subunits of succinyl CoA ligase within the cerebral cortex suggests the absence of matrix substrate-level phosphorylation in glial cells of the human brain.7
253704872015Localization of SUCLA2 and SUCLG2 subunits of succinyl CoA ligase within the cerebral cortex suggests the absence of matrix substrate-level phosphorylation in glial cells of the human brain.7
250273202014SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.26
250273202014SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.26
212951392011The interplay between SUCLA2, SUCLG2, and mitochondrial DNA depletion.25
212951392011The interplay between SUCLA2, SUCLG2, and mitochondrial DNA depletion.25
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.19
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.14

Citation

Dessen P

SUCLG2 (succinate-CoA ligase GDP-forming subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57513/suclg2-(succinate-coa-ligase-gdp-forming-subunit-beta)