Identity
HGNC
LOCATION
22q11.21
LOCUSID
ALIAS
BTBD29,LZTR-1,NS10,NS2,SWNTS2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8216
MIM: 600574
HGNC: 6742
Ensembl: ENSG00000099949
Variants:
dbSNP: 8216
ClinVar: 8216
TCGA: ENSG00000099949
COSMIC: LZTR1
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36445254 | 2023 | LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL. | 3 |
| 37509153 | 2023 | Exome Survey and Candidate Gene Re-Sequencing Identifies Novel Exstrophy Candidate Genes and Implicates LZTR1 in Disease Formation. | 0 |
| 37592023 | 2023 | Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk. | 7 |
| 37936555 | 2023 | Prenatal diagnosis of autosomal recessive Noonan syndrome associated with biallelic LZTR1 variants presented with thick nuchal translucency and cardiac abnormalities. | 0 |
| 36445254 | 2023 | LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL. | 3 |
| 37509153 | 2023 | Exome Survey and Candidate Gene Re-Sequencing Identifies Novel Exstrophy Candidate Genes and Implicates LZTR1 in Disease Formation. | 0 |
| 37592023 | 2023 | Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk. | 7 |
| 37936555 | 2023 | Prenatal diagnosis of autosomal recessive Noonan syndrome associated with biallelic LZTR1 variants presented with thick nuchal translucency and cardiac abnormalities. | 0 |
| 35114566 | 2022 | The GSK3 kinase and LZTR1 protein regulate the stability of Ras family proteins and the proliferation of pancreatic cancer cells. | 5 |
| 35840934 | 2022 | LZTR1 molecular genetic overlap with clinical implications for Noonan syndrome and schwannomatosis. | 4 |
| 35114566 | 2022 | The GSK3 kinase and LZTR1 protein regulate the stability of Ras family proteins and the proliferation of pancreatic cancer cells. | 5 |
| 35840934 | 2022 | LZTR1 molecular genetic overlap with clinical implications for Noonan syndrome and schwannomatosis. | 4 |
| 32576656 | 2021 | Sporadic vestibular schwannoma: a molecular testing summary. | 4 |
| 33407364 | 2021 | A Chinese family with Noonan syndrome caused by a heterozygous variant in LZTR1: a case report and literature review. | 4 |
| 34184824 | 2021 | Expanding the clinical phenotype of RASopathies in 38 Turkish patients, including the rare LZTR1, RAF1, RIT1 variants, and large deletion in NF1. | 6 |
Citation
Dessen P
LZTR1 (leucine zipper like transcription regulator 1)
Atlas Genet Cytogenet Oncol Haematol. 2018-07-01
Online version: http://atlasgeneticsoncology.org/gene/57519
